{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:35:21Z","timestamp":1756992921445},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T00:00:00Z","timestamp":1294790400000},"content-version":"vor","delay-in-days":14621,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1971,1]]},"abstract":"<jats:p>Arrest of imminent premature labour by \u03b2\u2010adrenergic stimulation often fails, due to undesirable side effects or lack of effectiveness. Inhibition of oxytocin release from the neurohypophysis by ethanol also has disadvantages.<\/jats:p><jats:p>\u03b1\u2010adrenergic stimulation in pregnant and non\u2010pregnant women increases uterine contractions, while blocking of \u03b1\u2010receptors in non\u2010pregnant patients has been shown to reduce uterine activity. A combination of adrenergic \u03b1\u2010blockade followed by \u03b2\u2010stimulation therefore might be more effective than \u03b2\u2010stimulation alone in the treatment of premature labour.<\/jats:p><jats:p>This combined regimen was used in 6 women at 16\u201320 weeks of pregnancy. The response to oxytocin\u2010induced uterine contractions was measured.<\/jats:p><jats:p>In mid\u2010pregnancy, blockade of \u03b1\u2010receptors did not reduce oxytocin\u2010induced activity, \u03b2\u2010stimulation reduced the uterine activity; this reduction seemed to be independent of \u03b1\u2010blockade.<\/jats:p><jats:p>The combination of \u03b1\u2010blockade and \u03b2\u2010stimulation did not seem to be superior to \u03b2\u2010stimulation alone.<\/jats:p>","DOI":"10.3109\/00016347109157299","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:12:10Z","timestamp":1260295930000},"page":"135-139","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inhibition of Oxytocin\u2010Induced Uterine Activity in Midpregnancy by Combined Adrenergic \u03b1\u2010Blockade and \u03b2\u2010Stimulation"],"prefix":"10.1111","volume":"50","author":[{"given":"Helge","family":"Jenssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(69)90171-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)34796-2"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90411-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/S0002-9378(16)36199-3","article-title":"The pharmacologic control of excessive uterine activity with isoxsuprine","volume":"82","author":"Hendricks Ch. 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