{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T06:55:01Z","timestamp":1699512901582},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T00:00:00Z","timestamp":1294790400000},"content-version":"vor","delay-in-days":14256,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1972,1]]},"abstract":"<jats:p>Using a new method for estimation of cystine aminopeptidase (CAP) activity in maternal serum, serial CAP determinations have been performed in 7 women during normal pregnancy, in 7 patients after delivery, in 10 patients with pre\u2010eclampsia, in 5 patients with suspected placental insufficiency and in 4 multiple pregnancies. The results were as follows.<\/jats:p><jats:p>The enzyme activity decreased slowly after delivery. The half\u2010life of the enzyme in maternal blood was calculated as 3\u20136 days except in one patient where only 20% of the enzyme activity was lost within 4 days. The decrease of CAP activity in serum after intra\u2010uterine foetal death was also very slow. In patients with uncomplicated mild toxaemia of pregnancy the CAP values were in the normal range. In patients with severe pre\u2010eclampsia the results varied. In one patient with acute severe pre\u2010eclampsia and a threatening eclamptic attack the CAP values were high, and this might be explained by the presence of non\u2010specific aminopeptidase activity in serum. In preeclampsia with associated retardation of foetal growth the CAP values were rather low, with decreasing values prior to foetal death. In patients with pronounced placental insufficiency the CAP values were consistently low, whereas high figures were often found in multiple pregnancy.<\/jats:p><jats:p>The observations indicate that determination of CAP in maternal serum might be a valuable parameter in judging the condition of the placenta. However, the significance of CAP assays in assessing placental function cannot be established until the method is compared with other placental function tests on the same clinical material.<\/jats:p>","DOI":"10.3109\/00016347209156868","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:11:29Z","timestamp":1260295889000},"page":"329-334","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cystine Aminopeptidase Activity in Pregnancy"],"prefix":"10.1111","volume":"51","author":[{"given":"Gunnar","family":"Ryd\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(66)90540-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1971.tb00309.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1971.tb00298.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1967.tb14870.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(69)90104-1"},{"issue":"96","key":"e_1_2_1_7_1","volume":"48","author":"Melander S. 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