{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:12:04Z","timestamp":1756995124329},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T00:00:00Z","timestamp":1294790400000},"content-version":"vor","delay-in-days":12429,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> The urinary excretion of histamine and its metabolites, methylhistamine, methylimidazoleacetic acid and imidazoleacetic acid, was measured under standardized dietary conditions in 24 women with normal pregnancies and in eleven patients with toxaemia of pregnancy. in addition, histamine metabolism was studied in five healthy women at delivery and in four other healthy pregnant women during treatment with aminoguanidine, which is an inhibitor of diamino oxidase (histaminase). A slight increase in the urinary excretion of methylimidazoleacetic acid was observed in normal pregnancy as well as in toxaemia of pregnancy compared to non\u2010pregnant women. in two toxaemic patients and in one of the healthy subjects the urinary excretion of unmetabolized histamine was moderately increased. Despite the very high diamino oxidase activity in the plasma and in the uterus during pregnancy, there were no signs of altered catabolism of endogenous histamine in the pregnant women. Smoking increased the urinary excretion of the quantitatively dominant histamine metabolite, methylimidazoleacetic acid, in pregnant subjects as it also does in nonpregnant subjects. the necessity of standardized dietary conditions in the study of histamine metabolism in man was again emphasized.<\/jats:p>","DOI":"10.3109\/00016347709158346","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:06:07Z","timestamp":1260295567000},"page":"81-86","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Histamine Metabolism in Normal Pregnancy and in Toxaemia of Pregnancy"],"prefix":"10.1111","volume":"56","author":[{"given":"G.","family":"Granerus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Gillbrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wetterqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016346109157856"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016346409157927"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1961.tb02111.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/S0021-9258(18)97421-1","article-title":"The presence and measurement of methylhistamine in urine","volume":"240","author":"Fram D. H.","year":"1965","journal-title":"J Biol Chem"},{"key":"e_1_2_1_6_1","first-page":"274","article-title":"Urinary excretion of histamine during pregnancy","volume":"5","author":"Graham H. T.","year":"1963","journal-title":"Pharmacologist"},{"issue":"104","key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/00365516809168041","article-title":"Urinary excretion of histamine, methylhistamine and methylimidazole acetic acids in man under standardized dietary conditions","volume":"22","author":"Granerus G.","year":"1968","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365516509075363"},{"issue":"104","key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/00365516809168039","article-title":"Histamine metabolism in healthy subjects before and during treatment with aminoguanidine","volume":"22","author":"Granerus G.","year":"1968","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1969.350.1.603"},{"key":"e_1_2_1_11_1","first-page":"235","article-title":"Zur Bestimmung von Imidazolessigsaure im Urin und ihr Vorkommen bei Urticaria pigmentosa","volume":"17","author":"Hanson A.","year":"1957","journal-title":"Naturwissenschaften"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1974.tb00541.x"},{"key":"e_1_2_1_13_1","volume-title":"Biogenesis and Physiology of Histamine","author":"Kahlson G.","year":"1971"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016346309158160"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016346309158163"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016346609158440"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1960.tb01255.x"},{"key":"e_1_2_1_18_1","volume-title":"Handbook of experimental Pharmacology","author":"Lindell S.\u2010E.","year":"1966"},{"key":"e_1_2_1_19_1","first-page":"313","article-title":"Metabolism of C14\u2010labelled histamine in pregnant and non\u2010pregnant women","volume":"18","author":"Nilsson K.","year":"1959","journal-title":"Clin Sci"},{"issue":"8","key":"e_1_2_1_20_1","article-title":"Histamine metabolism in pregnancy","author":"Rosengren E.","year":"1966","journal-title":"Acta Universitatis Lundensis, sectio II"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1152\/jappl.1956.9.3.481","article-title":"Metabolism of C14\u2010histamine in man","volume":"9","author":"Schayer R. W.","year":"1956","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5766.115-c"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365517009046212"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1966.tb01930.x"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016347709158346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016347709158346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T16:08:39Z","timestamp":1699459719000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016347709158346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.3109\/00016347709158346"],"URL":"https:\/\/doi.org\/10.3109\/00016347709158346","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]},"assertion":[{"value":"2011-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}