{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:10:03Z","timestamp":1760202603669},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T00:00:00Z","timestamp":1294790400000},"content-version":"vor","delay-in-days":12064,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> A case of malformations of the fetal central nervous system following hypervitaminosis A in early pregnancy is reported. The mother was treated with 150000 IU vitamin A daily during gestation days 19 to 40. Determination of urinary oestriol carried out in the 42nd week of pregnancy revealed a very low excretion (4.2\u20106.6 \u03bcmol\/24 h). Induced delivery resulted in a microcephalic child who died after 18 min. The child had multiple malformations of the central nervous system and very small adrenal glands (1.5 g; normal 11\u00b14g). The very low urinary oestriol excretion is well explained by the hypoplastic adrenals, which in turn can be related to insufficient ACTH stimulation, a condition similar to anencephaly. The malformations shown in the present case are considered to be related to the high doses of vitamin A given to the mother, and the authors wish to warn against uncritical use of high doses of vitamin A in women of childbearing age.<\/jats:p>","DOI":"10.3109\/00016347809154901","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:05:08Z","timestamp":1260295508000},"page":"289-291","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Hypervitaminosis a in early human pregnancy and malformations of the central nervous system"],"prefix":"10.1111","volume":"57","author":[{"given":"Lars","family":"St\u00e5nge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Carlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareta","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,12]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"750","article-title":"Hypervitaminosis A and congenital renal anomalies in a human infant","volume":"43","author":"Bernhardt I. 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M.","year":"1975","journal-title":"Clin Perinatol"},{"key":"e_1_2_1_15_1","first-page":"201","article-title":"The effect of added vitamin A alcohol on the metabolism of progesterone in the placenta of the guinea pig, Cavia porcellus","volume":"42","author":"Piziak V. K.","year":"1972","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_1_16_1","first-page":"504","article-title":"Uberdosierung von vitamin A","volume":"45","author":"Reuter H.","year":"1974","journal-title":"Hippokrates"},{"key":"e_1_2_1_17_1","first-page":"589","article-title":"Animal model. Treatment of various species with large dose of vitamin A at known stages in pregnancy","volume":"66","author":"Shenefelt R. E.","year":"1972","journal-title":"Am J Pathol"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016347809154901","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016347809154901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T17:50:14Z","timestamp":1699465814000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016347809154901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,1]]}},"alternative-id":["10.3109\/00016347809154901"],"URL":"https:\/\/doi.org\/10.3109\/00016347809154901","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]},"assertion":[{"value":"2011-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}