{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:07:06Z","timestamp":1786540026338,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T00:00:00Z","timestamp":1294790400000},"content-version":"vor","delay-in-days":12064,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:p><jats:bold>Abstract.<\/jats:bold>The haemodynamic effects of oxytocin (Syntocinon\u00ae) and methyl ergometrin (Methergin\u00ae) were studied in 9 healthy females in the first trimester of pregnancy. The patients were anaesthetized with sodium thiomebumal, pethidine and pancuronium bromide and ventilated on a Manley respirator. 10 i.u. oxytocin given as an i.v. bolus brought about a fall in femoral arterial pressure of 40%, systemic resistance 59% and pulmonary resistance 44% 30 sec after injection. However, the heart rate increased 31% and stroke volume 17%, so that the cardiac output increased by 54%. The pulmonary arterial pressure and wedge pressure were increased by 33% and 35%, respectively 150 sec after injection. No changes were seen in the haemodynamic parameters during infusion of 80 mU oxytocin for 10 min. 0.2 mg Methergin brought about an increase in the femoral arterial pressure of 11 %, pulmonary arterial pressure 27% and wedge pressure 31%, with no changes in the other measured parameters. The use of oxytocic drugs in patients with compromised circulation is discussed.<\/jats:p>","DOI":"10.3109\/00016347809155884","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:05:11Z","timestamp":1260295511000},"page":"97-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Haemodynamic Effects of Oxytocin (Syntocinon\u00ae) and Methyl Ergometrine (Methergin\u00ae) on the Systemic and Pulmonary Circulations of Pregnant Anaesthetized Women"],"prefix":"10.1111","volume":"57","author":[{"given":"N. J.","family":"Secher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Arnsbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331976701800703"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt196563345"},{"key":"e_1_2_1_4_1","first-page":"360","article-title":"Cardiovascular effects of intravenous syntocinon","volume":"13","author":"Berquist J. R.","year":"1959","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_5_1","first-page":"80","volume-title":"Oxytocin","author":"Bieniarz J.","year":"1961"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-49813-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5689.139"},{"key":"e_1_2_1_8_1","first-page":"1","author":"Ekelund L. G.","year":"1967","journal-title":"Central hemodynamics during exercises. Suppl. I to Circulation Research"},{"key":"e_1_2_1_9_1","first-page":"167","article-title":"Methergine: A study of its effects on blood pressure","volume":"8","author":"Fitzgerald W. J.","year":"1956","journal-title":"Obstet GynecoI"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1970.tb03464.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(70)90542-9"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/44.8.826"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196409000-00013"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1959.tb00965.x"},{"key":"e_1_2_1_15_1","first-page":"399","article-title":"Some actions of oxytocin on the cardiovascular system in man","volume":"18","author":"Kitchin H.","year":"1959","journal-title":"Clin Sci"},{"key":"e_1_2_1_16_1","first-page":"1208","article-title":"Development and evaluation of an impedance cardiac output system","volume":"37","author":"Kubicek W. G.","year":"1966","journal-title":"Aerospace Med"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1962.03050060020004"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(73)90529-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0022-3565(25)26659-9","article-title":"Studies on the cardiovascular effects of synthetic oxytocin","volume":"142","author":"Nakano J.","journal-title":"J Pharmacol Exper Therap"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196407000-00010"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/11.1.26"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0002-9378(51)90024-5","article-title":"Methergine: A study of its vasomotor properties","volume":"61","author":"Schade F. F.","year":"1951","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_23_1","first-page":"211","article-title":"Cardiovascular effects of oxytocin","volume":"46","author":"Weis F. R.","year":"1975","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1974.tb00523.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0022-3565(25)09089-5","article-title":"Effects of posterior pituitary extract, oxytocin (Pitocin) and ergonovine hydracrylate (Ergotrate) on uterine, arterial, venous and maternal effective placental arterial pressures in pregnant humans","volume":"80","author":"Woodbury R. A.","year":"1944","journal-title":"J Pharmacol Exp Therap"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-3565(25)08809-3","article-title":"Cardiac and blood pressure effects of pitocin (oxytocin) in man","volume":"81","author":"Woodbury R. A.","year":"1944","journal-title":"J Pharmacol Exp Therap"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016347809155884","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016347809155884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T18:16:47Z","timestamp":1739470607000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016347809155884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1978,1]]}},"alternative-id":["10.3109\/00016347809155884"],"URL":"https:\/\/doi.org\/10.3109\/00016347809155884","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]},"assertion":[{"value":"2011-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}