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Triglycerides increased by 18\u201042 per cent after one to six months of treatment with 50\/125. the HDL\u2010cholesterol and HDL\u2010phospholipids were reduced by 10 per cent during 50\/250 medication. No other parameters showed any consistent alteration in any of the treatment groups. Raised triglyceride concentration and\/or decreased HDL concentration may increase the risk for cardiovascular disease. It is therefore suggested that in order not to alter the HDL concentration a combined oral contraceptive agent should probably not contain more 19\u2010nortestosterone type of progestogen than corresponding to 125\u2010150 \u03bcg of levonorgestrel. to avoid a rise of the triglyceride level the weight relation between levonorgestrel and ethinyl estradiol should be about 5:1.<\/jats:p>","DOI":"10.3109\/00016347909157230","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:03:45Z","timestamp":1260295425000},"page":"57-60","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["EFFECTS OF THREE DIFFERENT COMBINATIONS OF ETHINYL ESTRADIOL AND LEVONORGESTREL ON PLASMA LIPIDS AND HIGH DENSITY LIPOPROTEINS"],"prefix":"10.1111","volume":"58","author":[{"given":"Ulf","family":"Larsson\u2010Cohn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Wallentin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Zador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197807062990104"},{"key":"e_1_2_1_3_1","first-page":"126","article-title":"Biochemical effects of oral contraceptives","volume":"5","author":"Briggs M.H","year":"1976","journal-title":"Adv Steroid Biochem Pharmacol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(58)90364-4"},{"key":"e_1_2_1_5_1","first-page":"196","article-title":"Alpha\u2010lipoprotein cholesterol, beta\u2010lipoprotein cholesterol and longevity","volume":"2","author":"Glueck C.J","year":"1976","journal-title":"Artery"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1001\/jama.1978.03280410045016","article-title":"Oral contraceptives and nonfatal myocardial infarction","volume":"239","author":"Jick H.","year":"1978","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290230040022"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1093969"},{"key":"e_1_2_1_9_1","first-page":"717","article-title":"Effects of combined and low dose gestagens on plasma lipids including individual phospholipids","volume":"63","author":"Larsson\u2010Cohn U.","year":"1970","journal-title":"Acta Endocrinol (Kbh)"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1092755"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6033.445"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02533850"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112646"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91205-4"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)39550-4"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92247-1"},{"key":"e_1_2_1_17_1","first-page":"597","article-title":"Metabolic and hormonal effects of post\u2010menopausal oestrogen replacement. 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