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During a period of observation of 6\u201042 months (average 18 months) the cervical intraepithelial neoplasia (CIN) regressed in 54 per cent.<\/jats:p><jats:p>Cryosurgery was used to treat 93 patients with persistent CIN after biopsy. Treatment was successful in almost 70 per cent after one single application of cryosurgery. The complications were negligible. Treatment was less successful with increasing histological severity as well as with increasing age of the patients; this applies both to biopsy and cryosurgery. Cryosurgery is significantly less effective when the CIN is of both ecto\u2010 and endocervical origin.<\/jats:p><jats:p>Extensive multiple biopsies of the portio in combination with endocervical curettage performed under general anaesthesia, followed by cryosurgery with persistent cytological abnormalities, are indicated as an alternative to conization, especially in younger patients with ectocervical CIN.<\/jats:p>","DOI":"10.3109\/00016348009154092","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:02:58Z","timestamp":1260295378000},"page":"349-353","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of cervical intraepithelial neoplasia with local excisional biopsy and cryosurgery"],"prefix":"10.1111","volume":"59","author":[{"given":"Svein\u2010Erik","family":"Tronstad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347709155026"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90584-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-197509000-00024"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347809154031"},{"key":"e_1_2_1_6_1","first-page":"1974","article-title":"Carcinoma in situ cervicis uteri","volume":"61","author":"Eliasson G.","year":"1964","journal-title":"L\u00e4kartidningen"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90629-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347709155007"},{"key":"e_1_2_1_9_1","first-page":"54","article-title":"The management and natural history of severe dysplasia and carcinoma in situ of the uterine cervix","volume":"83","author":"Grad C.","year":"1976","journal-title":"Br J Obstet Gynaecol"},{"key":"e_1_2_1_10_1","first-page":"1739","article-title":"Konisation behandling av preinvasiv cervixcancer. 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(Is conization indicated in carcinoma in situ cervicis uteri?)","volume":"70","author":"Lundstr\u00f6m P.","year":"1973","journal-title":"L\u00e4kartidningen"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)92541-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90900-5"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90476-2"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33348-8"},{"key":"e_1_2_1_22_1","first-page":"2933","article-title":"Cryokirurgi vid dysplasi och carcinoma in situ. Kliniska erfarenheter (Cryosurgical treatment of dysplasia and carcinoma in situ.)","volume":"71","author":"Stendahl V.","year":"1974","journal-title":"L\u00e4kartidningen"},{"key":"e_1_2_1_23_1","article-title":"Crysurgery techniques, symposium","volume":"5","author":"Townsend D. 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