{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:41:38Z","timestamp":1757702498212},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":11333,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:p>In a prospective investigation biopsy specimens were obtained of 150 women with primary, untreated endometrial carcinoma for determination of the content of estrogen and progesterone receptors (E<jats:sub>2<\/jats:sub> and PR). After a varying interval 13 who developed metastases despite routine surgical and radiation therapy received treatment with gestagens. The clinical effect of the hormone was studied for any correlation with the initial content of E<jats:sub>2<\/jats:sub> and PR.<\/jats:p><jats:p>Eight of the women (61\u201371 years) proved E<jats:sub>2<\/jats:sub>R positive (&gt; 10 fmoles\/mg cytosolprotein), 2 had no PR and the remaining 6 had PR in a concentration of 7\u2013892 fmoles\/mg cytosolprotein). 7 responded clinically to gestagen therapy (tumors poorly differentiated in 3 and moderately in 4).<\/jats:p><jats:p>Five of the women (50\u201384 years) were E<jats:sub>2<\/jats:sub>R negative; they had no PR, they did not respond to gestagen therapy and died after 2\u20138 months (tumors poorly differentiated in 2 and moderately in 3).<\/jats:p><jats:p>Determination of E<jats:sub>2<\/jats:sub>R and PR in endometrial carcinoma appears to be a clinically useful test for predicting whether a patient is likely to respond to treatment with gestagens.<\/jats:p>","DOI":"10.3109\/00016348009154633","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:03:16Z","timestamp":1260295396000},"page":"155-159","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Do Estrogen and Progesterone Receptors (E<sub>2<\/sub>R and PR) in Metastasizing Endometrial Cancers Predict the Response to Gestagen Therapy?"],"prefix":"10.1111","volume":"59","author":[{"given":"Th. J.","family":"Benraad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. G.","family":"Friberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. M.","family":"Koenders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kullander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Progesterone Receptors in Normal and Neoplastic Tissues","author":"Bayard F.","year":"1977"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(78)90006-9"},{"key":"e_1_2_1_4_1","first-page":"7","article-title":"Progesterone receptors \u2013 a new approach to recurrent endometrial cancer","volume":"18","author":"Ehrlich C. 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B..1978 Personal communication."},{"key":"e_1_2_1_12_1","first-page":"4669","article-title":"Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer","volume":"37","author":"Knight W. A.","year":"1977","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_1","volume-title":"Progesterone Receptors in Normal and Neoplastic Tissues","author":"Koenders A. J. 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