{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:57:57Z","timestamp":1780333077863,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":10967,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:p>Pethidine (100 mg) was administered i.m. to women in labor at different times before delivery. The interval before respiration in the newborn became sustained was shorter if pethidine was given less than one hour before delivery. The respiratory rate of the newborn increased after naloxone injection in 40 per cent of the cases, mostly when intrauterine exposure to pethidine exceeded one hour. The plasma concentrations of pethidine and norpethidine were measured in mother and newborn. The concentrations in the umbilical vein and artery indicated a continuous net transfer of pethidine from mother to fetus for approximately two hours. This correlates with the clinical finding of maximal neonatal depression 2\u20133 hours after maternal injection. The concentrations of norpethidine increased with a longer time interval between injection and delivery, but were probably too low to have any effect on the newborn. Neonatal depression seems to be related to the amount of unmetabolized pethidine that has been transferred from mother to fetus but not to norpethidine as had been suspected earlier.<\/jats:p>","DOI":"10.3109\/00016348109154108","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:02:38Z","timestamp":1260295358000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Neonatal depression after obstetrical analgesia with pethidine. the role of the injection\u2010delivery time interval and of the plasma concentrations of pethidine and norpethidine"],"prefix":"10.1111","volume":"60","author":[{"given":"P.","family":"Belfrage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. O.","family":"Bor\u00e9us","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hartvig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Irestedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Raabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1963.tb01468.x"},{"key":"e_1_2_1_3_1","first-page":"289","article-title":"The physiological disposition and fate of meperidine (Demerol) in man and a method for its estimation in plasma","volume":"114","author":"Burns J. J.","year":"1955","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(78)90338-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1975.tb10692.x"},{"key":"e_1_2_1_6_1","first-page":"108","article-title":"Pharmacokinetics and analgesic effect of pethidine and pethidine metabolites in the rat","volume":"7","author":"Dahlstr\u00f6m B. E.","year":"1979","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_1_7_1","first-page":"98","article-title":"Type of toxicity in the monkey as influenced by the rate of metabolic conversion of meperidine to normeperidine","volume":"2","author":"Deneau G. A.","year":"1960","journal-title":"Pharmacologist"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1976205546"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6044.1098"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80583-0"},{"key":"e_1_2_1_11_1","first-page":"196","article-title":"Les effets sur le nouveau\u2010n\u00e9 de la p\u00e9thidine","volume":"52","author":"Guilhem P.","year":"1953","journal-title":"Gyn\u00e9cologie et Obst\u00e9trique"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00561790"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/49.9.891"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1974164667"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(79)90310-7"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(79)90311-9"},{"key":"e_1_2_1_17_1","first-page":"1","article-title":"Biological fate of pethidine","volume":"33","author":"Lindberg C.","year":"1978","journal-title":"Thesis, Faculty of Pharmacy, Acta Universitatis Upsaliensis"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1946.tb00022.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt197517121"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1976205535"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197803050-00002"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0016-5085(75)80289-7","article-title":"Effect of acute ciral hepatitis in man on the disposition and elimination of meperidine","volume":"8","author":"McHorse T. S.","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0022-3565(25)11314-1","article-title":"The effect of N\u2010demethylation on certain pharmacologic actions of morphine, codeine and meperidine in the mouse","volume":"112","author":"Miller J. W.","year":"1954","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(73)90564-4"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/49.6.525"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0022-3565(25)07800-0","article-title":"The metabolism of N\u2010C14H3 labeled meperidine","volume":"104","author":"Plotnikoff N. P.","year":"1952","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0022-3565(25)11695-9","article-title":"Biotransformation products of meperidine excreted in the urine of man","volume":"117","author":"Plotnikoff N. P.","year":"1956","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01861099"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(64)90292-3"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1976.tb02401.x"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-6-738"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1978.tb01293.x"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016348109154108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016348109154108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T18:15:38Z","timestamp":1739470538000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016348109154108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.3109\/00016348109154108"],"URL":"https:\/\/doi.org\/10.3109\/00016348109154108","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]},"assertion":[{"value":"2011-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}