{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T06:55:39Z","timestamp":1699512939970},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":10967,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> Fifteen cases of primary carcinoma in situ or severe or moderate dysplasia of the vagina have been diagnosed and treated during the period 1966\u201375 at the Department of Obstetrics and Gynecology, Turku University Central Hospital. Because of abnormal vaginal cytology the lesion was localized by means of colposcopy and iodine staining. For 6 patients local estrogen treatment was applied to increase the thickness of the epidermal layer. For 6 patients, treatment consisted of simple excision. Nine patients, including both those with carcinoma in situ, were treated with intravaginal radiation therapy. The radiation dosage was 2000 to 2600 rad at a distance of 1 cm from the surface of the epithelium. None of the patients showed any complications, and all are now symptom\u2010free.<\/jats:p>","DOI":"10.3109\/00016348109155472","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:02:15Z","timestamp":1260295335000},"page":"513-514","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["DIAGNOSIS AND TREATMENT OF PRIMARY VAGINAL CARCINOMA IN SITU AND DYSPLASIA"],"prefix":"10.1111","volume":"60","author":[{"given":"R.","family":"Punnonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gr\u00f6nroos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Meurman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Liukko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1971)28:5<1278::AID-CNCR2820280528>3.0.CO;2-O"},{"key":"e_1_2_1_3_1","first-page":"334","article-title":"Carcinoma in situ of the vagina","volume":"46","author":"Gallup D. 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