{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:13:20Z","timestamp":1759335200773},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":10967,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> Ten women with essential hirsutism were treated for one year with cyclic administration of cyproterone acetate and ethinyl estradiol. Biochemical and clinical control took place after 1, 3, 6 and 12 months of treatment.<\/jats:p><jats:p>In 4 patients great improvement of hirsutism was noted, but only after 6 months of therapy. In 4 patients there was some improvement, while 2 were resistant. Side effects included reduced libido in 4 cases, mental depression in 3, dry skin and itching in 4 and transient nausea in one, but never necessitated cessation or interruption of treatment.<\/jats:p><jats:p>Several changes in endocrine function took place during treatment: testosterone secretion rate diminished together with the urinary excreetion of 17\u2010KS and 17\u2010KGS, while the serum concentration of testosterone binding globulin increased. There was a reduction in the serum concentration of total endogenous estrogens and progesterone as well as LH. No changes in hepatic, renal or hematologic parameters were found except for a slight increase in plasma pro\u2010thrombin time.<\/jats:p><jats:p>Clinical outcome of therapy could not be correlated with a pretreatment endocrine \u201cprofile\u201d, nor with the changes that this therapy induced in endocrine function.<\/jats:p><jats:p>It is concluded that the anti\u2010androgenic effect is probably the most important in this drug regimen, but that reversibility of hirsutism may depend upon factors not directly related to androgen influence.<\/jats:p>","DOI":"10.3109\/00016348109158134","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:02:33Z","timestamp":1260295353000},"page":"295-300","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["THE TREATMENT OF ESSENTIAL HIRSUTISM IN WOMEN WITH CYPROTERONE ACETATE AND ETHINYL ESTRADIOL"],"prefix":"10.1111","volume":"60","author":[{"given":"Harald","family":"Frey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asbj\u00f8rn","family":"Aakvaag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1978.tb00573.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105588"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1975.tb03305.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01347138"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0360373"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365517409082499"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1977.tb12537.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb14244.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0220031"},{"key":"e_1_2_1_11_1","first-page":"573","article-title":"Hormonale Behandlung der Hirsutismus","volume":"106","author":"Floersheim Y.","year":"1976","journal-title":"Schweitz Med Wochenschr"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0022-5347(17)58281-6","article-title":"Hormone changes in patients with prostatic carcinoma during treatment with estramustine phosphate","volume":"118","author":"Foss\u00e5 S. 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