{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T06:56:23Z","timestamp":1699512983309},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":10602,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> A group of 782 patients with a diagnosis of acute salpingitis (a few of the patients because of other infection in the pelvis) were treated with the recommended oral dose of doxycycline (200 mg the first day and 100 mg once daily for at least the following 9\u201312 days) in combination with 1 g benzyl penicillin and 0.6 g procaine penicillin twice daily intramuscularly for 5\u20137 days. The plasma concentrations of doxycycline were determined on the third day of treatment before the next dose was given. In 26.5% of the patients the concentrations were below 1 \u03bcg\/ml plasma, considered as the minimum therapeutic level. The dose of doxycycline was increased to 200 mg a day in these patients and the plasma concentrations increased accordingly. In another group of 80 patients, 40 were treated with the standard doxycycline dose, and the other 40 patients with the standard lymecycline dose (300 mg twice a day). The plasma concentrations, determined before the dose on the third day, were below 1 \u03bcg\/ml in 35% of the patients treated with doxycycline, and in 5% of those treated with lymecycline. Since acute salpingitis in most cases is a serious complication to a lower genital tract infection, often a sexually transmitted disease caused by tetracycline\u2010sensitive organisms, the importance of achieving and determining the therapeutic plasma concentrations of tetracyclines is stressed.<\/jats:p>","DOI":"10.3109\/00016348209156953","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:01:52Z","timestamp":1260295312000},"page":"59-64","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antibiotic Treatment of Acute Salpingitis"],"prefix":"10.1111","volume":"61","author":[{"given":"Lars","family":"Forslin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Danielson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kjellander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viking","family":"Falk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348209156951"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-195902020-00024"},{"key":"e_1_2_1_4_1","first-page":"221","article-title":"Antibiotic susceptibility of Neisseria gonorrhoeae in relation to serogroups","volume":"89","author":"Bygdeman S.","year":"1981","journal-title":"Acta Pathol Microbiol Scand, Sect B"},{"key":"e_1_2_1_5_1","first-page":"95","article-title":"Lymecycline or doxycycline for treatment of urinary tract infections: a comparison of attained urine concentrations","volume":"20","author":"Ericsson S.","year":"1977","journal-title":"Microbios"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197507242930403"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-197603000-00013"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(46)90360-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016346509158538"},{"key":"e_1_2_1_10_1","first-page":"82","article-title":"Tetracycline interference with the bactericidal effect of serum","volume":"244","author":"Forsgren A.","year":"1973","journal-title":"Nature"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.3.6.711"},{"key":"e_1_2_1_12_1","first-page":"247","article-title":"Changes in the incidence of acute gonococcal and non\u2010gonococcal salpingitis. A five\u2010year study from an urban area of central Sweden","volume":"54","author":"Forslin L.","year":"1977","journal-title":"Br J Vener Dis"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1128\/iai.5.1.98-102.1972","article-title":"Classification of Neisseria meningitidis group B into district serotypes. I. Serological typing by microbactericidal method","volume":"5","author":"Frasch C. E.","year":"1972","journal-title":"Infect Immun"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347809155893"},{"key":"e_1_2_1_15_1","first-page":"19","volume-title":"Biologie und Pathologie des Weibes, Bd. V","author":"Heynemann T.","year":"1953"},{"key":"e_1_2_1_16_1","first-page":"695","article-title":"Comparison of serum and urine concentrations of doxycycline and tetracycline phosphate complex","volume":"11","author":"Holvey D. 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The correlation between the dose of pinicillin, concentration in blood, IC50\u2010values of gonococci and results of treatment","volume":"45","author":"Krook G.","year":"1965","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_1_21_1","volume-title":"A study on penicillins, tetracycline, streptomycin and rifampicin","author":"Malmborg A.\u2010S","year":"1974"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-197710000-00001"},{"key":"e_1_2_1_23_1","first-page":"179","article-title":"Tubal and cervical cultures in acute salpingitis with special reference to Mycoplasma hominis and T\u2010strain mycoplasmas","volume":"46","author":"M\u00e5rdh P.\u2010A.","year":"1970","journal-title":"Br J Vener Dis"},{"key":"e_1_2_1_24_1","first-page":"53","volume-title":"Genital Infections and Their Complications","author":"M\u00e5rdh P.\u2010A.","year":"1975"},{"key":"e_1_2_1_25_1","first-page":"77","volume-title":"Non\u2010gonococcal Urethritis and Related Infections","author":"M\u00e5rdh P.\u2010A.","year":"1977"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5734.532"},{"key":"e_1_2_1_27_1","first-page":"205","article-title":"Gonococcal salpingitis","volume":"45","author":"Rees E.","year":"1969","journal-title":"Br J Vener Dis"},{"key":"e_1_2_1_28_1","first-page":"1062","article-title":"Ueber die Ursachen von Eileiter\u2010enz\u00fcndungen","volume":"63","author":"Stemmer W.","year":"1941","journal-title":"Zentralbl Gynaekol"},{"key":"e_1_2_1_29_1","first-page":"260","volume-title":"Antibiotika Fibel, 3rd edn","author":"Walter A. 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