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Total hydrolysis (i.e. formation of [<jats:sup>3<\/jats:sup>H] estrone+ [<jats:sup>3<\/jats:sup>H] estradiol\u201017\u03b2) of [<jats:sup>3<\/jats:sup>H] estrone sulfate as well as formation of [<jats:sup>3<\/jats:sup>H] estradiol\u201017\u03b2 only was significantly less in group I than in the other groups. The formation of [<jats:sup>3<\/jats:sup>H] estradiol\u201017\u03b2 was greater in group V than in the other groups. 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