{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:55:48Z","timestamp":1761540948168},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":10237,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> In the present phase II trial, 26 heavily pretreated patients with advanced recurrent ovarian carcinoma were treated with tranexamic acid, 4 \u2212 6 g per os daily for at least 3 months. Of these 26 patients, 3 had stage IIb, 21 stage III and 2 stage IV. Histologic examination revealed serous adenocarcinoma in 13, mucinous in 3, endometroid in 4, 1 anaplastic and 5 unspecified adenocancer. Twenty of the tumors were poorly differentiated and 5 highly\u2010moderately differentiated. No objective response was noted but all the highly\u2010moderately differentiated tumors showed a stable disease state with a median duration of 6 months (range 4 \u2014 36 months). The patients with poorly differentiated tumors had a median survival of 4 months. Most of the patients had some form of gastro\u2010intestinal side effect. This investigation has shown that treatment with tranexamic acid was not particularly helpful in poorly differentiated cases in which modern combined chemotherapy already had failed. The effect in highly\u2010moderately differentiated cases needs further evaluation.<\/jats:p>","DOI":"10.3109\/00016348309155805","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T18:00:18Z","timestamp":1260295218000},"page":"265-266","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tranexamic Acid for the Treatment of Advanced Ovarian Carcinoma"],"prefix":"10.1111","volume":"62","author":[{"given":"Kristjan","family":"Sigurdsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u2010Erik","family":"Johnsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Trop\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"640","article-title":"Carcinoma of the ovary","volume":"58","author":"Allan M. S.","year":"1949","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_3_1","first-page":"11","article-title":"Advances in the histopathology of ovarian tumours. Advances in the biosciences","volume":"26","author":"Fox H.","year":"1980","journal-title":"Ovarian Cancer"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1962.24"},{"key":"e_1_2_1_5_1","first-page":"913","article-title":"Medroxyprogesterone\u2010acetate for the treatment of recurrent ovarian carcinoma","volume":"61","author":"Malkasian G. D.","year":"1977","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_6_1","unstructured":"MangioniC. LaVecchiaC. FranceschiS..Proges\u2010tin treatment in advanced epithelial ovarian cancer. 12th International Congress of Chemotherapy Florence Italy 11\u201324 July 1981 Abstract 275."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-197803000-00021"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(77)90007-5"},{"key":"e_1_2_1_9_1","first-page":"555","article-title":"Progesterone therapy for ovarian carcinoma","volume":"79","author":"Ward H. W.C","year":"1972","journal-title":"J Obstet Gynecol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03280020058026"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1977.tb15735.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01970136"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016348309155805","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016348309155805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T18:00:47Z","timestamp":1697738447000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016348309155805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.3109\/00016348309155805"],"URL":"https:\/\/doi.org\/10.3109\/00016348309155805","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]},"assertion":[{"value":"2011-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}