{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T12:17:36Z","timestamp":1700396256748},"reference-count":23,"publisher":"Wiley","issue":"S123","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":9872,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> Peripheral serum levels of dehydroepiandrosterone sulfate (DHAS), dehydroepiandrosterone (DHA), an\u2010drostenedione (A4) and testosterone (T) were measured in two groups of premenopausal women with fibrocystic breast disease, given 200 and 400 mg of danazol a day respectively for 6 months. During treatment, DHAS levels increased and DHA, DHA\/DHAS ratio, A4, and T decreased. A tendency towards dose dependency was observed. The changes in DHAS, DHA and DHA\/DHAS ratio were interpreted as resulting from inhibition of liver sulfatase activity by danazol. The decreased A4 and T levels probably reflect a suppression of ovarian steroidogenesis due to enzyme inhibition by danazol, and for the latter steroid also an increased metabolism due to interaction of the drug with sex hormone\u2010binding globulin.<\/jats:p>","DOI":"10.3109\/00016348409156998","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T17:58:18Z","timestamp":1260295098000},"page":"125-129","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Peripheral levels of dehydroepiandrosterone sulfate, dehydroepiandrosterone, androstenedione, and testosterone following different doses of danazol"],"prefix":"10.1111","volume":"63","author":[{"given":"Kjell","family":"Carlstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"D\u00f6berl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sten","family":"Gershagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Rannevik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)42732-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0002-9378(81)90611-6","article-title":"Danazol: Endocrine pharmacology and therapeutic applications","volume":"14","author":"Barbieri R. L.","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347909154578"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46940-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348409156994"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1980.tb04550.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(81)80041-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46757-9"},{"key":"e_1_2_1_10_1","first-page":"75","article-title":"Danazol: Endocrine and endometrial effects","volume":"25","author":"Floyd W. S.","year":"1980","journal-title":"Int J Fertil"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348409156997"},{"key":"e_1_2_1_12_1","first-page":"448","article-title":"Sex steroid levels during treatment of endometriosis","volume":"54","author":"Hirschowitz S. J.","year":"1979","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-5-719"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)33318-4"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46941-4"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-53-1-69"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1981.tb02966.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(82)90041-3"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/clinchem\/27.4.603","article-title":"Positive interference by danazol in a testosterone radioimmunoassay kit procedure","volume":"27","author":"Sharp A. M.","year":"1981","journal-title":"Clin Chem"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-32-4-522"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0015-0282(16)44657-1","article-title":"Inhibition of adrenal steroidogenesis by danazol in vivo","volume":"33","author":"Stillman R. J.","year":"1980","journal-title":"Fertil Steril"},{"key":"e_1_2_1_22_1","first-page":"153","volume-title":"Radioimmunoassay and Related Techniques","author":"Thorell J. I.","year":"1978"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0015-0282(16)43989-0","article-title":"The \u201ctreatment\u201d of explained infertility with danazol","volume":"31","author":"Dijk J. G.","year":"1979","journal-title":"Fertil Steril"},{"key":"e_1_2_1_24_1","unstructured":"vanEyckJ. DhontM. VandekerckhoveD. vanLucheneE. VoorhoofL. DelbekeL..Danazol treatment of chronic cystic mastopathy: A clinical and hormonal evaluation. Proceedings of the Benelux Danatrol Symposium A. C.Schellen.European Press Gent1978;51."}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016348409156998","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016348409156998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T23:19:26Z","timestamp":1697757566000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016348409156998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":23,"journal-issue":{"issue":"S123","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.3109\/00016348409156998"],"URL":"https:\/\/doi.org\/10.3109\/00016348409156998","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]},"assertion":[{"value":"2011-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}