{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:20:18Z","timestamp":1697775618967},"reference-count":14,"publisher":"Wiley","issue":"S123","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":9872,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> This study aimed at providing a detailed anam\u2010nestic, clinical, and mammographical characterization of 109 patients with fibrocystic breast disease, who were selected on the basis of pronounced mastodynia, prominent palpable structure and mammographical confirmation of the clinical diagnosis. Since these patients were selected for subsequent therapy, and most of them also underwent various hormonal investigations, accurate differential diagnosis was considered essential. Therefore, X\u2010ray mammography was supplemented as required with adenography, galactography, and aspiration of cysts followed by aerography. Additionally, the results for most study variables were recorded by means of standardized scoring systems.<\/jats:p><jats:p>On the basis of this characterization, three diagnostic sub\u2010groups of fibrocystic disease could be distinguished: 20 patients with prominent glandular structure but no visible cysts (group A), 43 patients with prominent glandular structure as well as small (&lt;1 cm) cysts (group B), and 46 patients with both small and large (\u2265 1 cm) cysts. The three groups differ significantly in mean age (33.1\u00b15.5 (SD), 39.2\u00b14.9, and 43.7\u00b14.6 years in groups A, B, and C, respectively). There was a significant trend towards increasing duration of breast complaints, and patients with a history of &gt;5 years account for 45, 65, and 74% in groups A, B, and C, respectively. Moreover, most of the study variables, viz. mastodynia, palpable structure, amount of glandular tissue, non\u2010cystic nodularity, small cysts, duct ectasia, nipple discharge, and fibrosis, also tended to increase significantly in intensity and\/or frequency from group A to B to C.<\/jats:p><jats:p>These findings strongly support the view that fibrocystic breast disease is a benign progressive process and that the three diagnostic sub\u2010groups represent different stages of this condition.<\/jats:p>","DOI":"10.3109\/00016348409157004","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T17:58:18Z","timestamp":1260295098000},"page":"151-155","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patient characteristics and age\u2010dependent sub\u2010populations in severe fibrocystic breast disease\u2014the Hj\u00f8rring project"],"prefix":"10.1111","volume":"63","author":[{"given":"Thorkild","family":"Rasmussen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Tobiassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"181","article-title":"Treatment of benign breast disease with danazol: A follow\u2010up report","volume":"21","author":"Aksu M. F.","year":"1978","journal-title":"J Reprod Med"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33237-9"},{"issue":"3","key":"e_1_2_1_4_1","first-page":"101","volume":"5","author":"Blackmore W. P.","year":"1977","journal-title":"Danazol in the treatment of benign breast diseaser Res"},{"issue":"5","key":"e_1_2_1_5_1","first-page":"52","article-title":"Danazol treatment of benign breast disease: A survey of U. S. A. multi\u2010centre studies","volume":"55","author":"Brookshaw J. D.","year":"1979","journal-title":"Postgrad Med J"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348409157005"},{"issue":"5","key":"e_1_2_1_7_1","first-page":"66","article-title":"Danazol treatment of chronic cystic mastopathy: A clinical and hormonal evaluation","volume":"55","author":"Dhont M.","year":"1979","journal-title":"Postgrad Med J"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-194511000-00032"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)38045-1"},{"issue":"5","key":"e_1_2_1_10_1","first-page":"48","article-title":"Aspects of fibrocystic disease of the breast. Treatment with danazol","volume":"55","author":"Humphrey L. J.","year":"1979","journal-title":"Postgrad Med J"},{"key":"e_1_2_1_11_1","first-page":"93","article-title":"The effect of danazol in the treatment of chronic cystic mastitis","volume":"48","author":"Lauersen N. H.","year":"1976","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_12_1","first-page":"291","article-title":"Fibrocystic disease of the breast","volume":"22","author":"Leis H. P.","year":"1979","journal-title":"J Reprod Med"},{"key":"e_1_2_1_13_1","first-page":"127","volume-title":"Endocrinology of Cystic Breast Disease","author":"Rannevik G.","year":"1983"},{"key":"e_1_2_1_14_1","first-page":"2495","article-title":"Mammography. Results obtained in a special clinic during a 12\u2010year period","volume":"139","author":"Rasmussen Th","year":"1977","journal-title":"Ugeskr L\u00e6g"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348409157006"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016348409157004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016348409157004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T23:20:01Z","timestamp":1697757601000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016348409157004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":14,"journal-issue":{"issue":"S123","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.3109\/00016348409157004"],"URL":"https:\/\/doi.org\/10.3109\/00016348409157004","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]},"assertion":[{"value":"2011-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}