{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:01:03Z","timestamp":1793145663974,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":9141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:p>Production of prostacyclin(PGI<jats:sub>2<\/jats:sub>)\u2010like activity in umbilical arteries in vitro was evaluated in 38 selected newborn infants. Nineteen of the mothers of these infants were habitual smokers and the remaining 19 were non\u2010smokers. to rule out the possibility of disturbing effects of drugs or other factors, the newborn infants and their mothers fulfilled strict criteria regarding normality and control of drug intake. the infants of habitual smokers (&gt;5 cigarettes\/day) (n = 19) were compared with a control group (n = 19) with non\u2010smoking mothers. Smokers' babies had lower birth weights than the controls (3 500\u00b1440 vs 3 900\u00b1420 g, p&lt;0.01). Production of PGI<jats:sub>2<\/jats:sub>\u2010like activity was estimated by a bioassay technique. Umbilical arteries of smokers' infants produced significantly less PGI<jats:sub>2<\/jats:sub>\u2010like activity (139\u00b178 ng\/g arterial tissue) than those of the controls (201\u00b187 ng\/g) (p&lt;0.05). As expected, the two groups differed highly significantly regarding serum levels of markers for exposure to cigarette smoke, but these levels did not correlate to formation of PGI<jats:sub>2<\/jats:sub>. Decreased production of PGI<jats:sub>2<\/jats:sub>\u2010like activity in umbilical vessels might have an impact on nutritive blood flow and oxygen transport, especially in situations of asphyxia.<\/jats:p>","DOI":"10.3109\/00016348609158403","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T17:55:53Z","timestamp":1260294953000},"page":"645-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Maternal Smoking Reduces Prostacyclin Formation in Human Umbilical Arteries: A Study on Strictly Selected 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