{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T06:44:49Z","timestamp":1697957089827},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":8776,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:p>Immunoreactive trypsin (IRT) has been studied in amniotic fluid as a possible complementary test substance for the prenatal diagnosis of cystic fibrosis (CF). 219 normal amniotic fluids have been tested in order to establish the normal ranges from 14 to 40 gestational weeks (g.w.). The IRT level increases from g.w. 14 to 19, remains stable from g.w. 19 to 25 and then decreases rapidly to low levels. A retrospective study of 4 presumed CF fluids, as determined by abnormal alkaline phosphatase levels, showed decreased IRT values in 3 out of 4 fluids. The difference between the mean value and the normal mean was not significant. The prospective study allowed us to test 2 fluids from pregnancies affected by meconium ileus. IRT level was highly elevated, 530 times the normal mean value at g.w. 34 for a non\u2010CF fetus and 18 times the normal mean value for a CF fetus at g.w. 31. In 4 out of 5 cases of fetal severe intra\u2010uterine growth retardation, IRT levels appeared mildly elevated. Other abnormalities are reviewed.<\/jats:p>","DOI":"10.3109\/00016348709022061","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:05:22Z","timestamp":1194980722000},"page":"587-590","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Amniotic immunoreactive trypsin in pregnancies with normal and pathological outcomes"],"prefix":"10.1111","volume":"66","author":[{"given":"Dominique","family":"Laroche","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Herlicoviez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Pasquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Travert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvon","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90825-0"},{"key":"e_1_2_1_3_1","first-page":"295","article-title":"D\u00e9pistage n\u00e9onatal syst\u00e9matique de la mucoviscidose par dosage de la trypsine im\u2010munor\u00e9active sanguine. Bilan de 80000 tests","volume":"40","author":"Travert G.","year":"1983","journal-title":"Arch Fr P\u00e9diatr"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80653-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92860-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1984.tb04782.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1982.tb04681.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970050203"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(79)80021-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90477-5"},{"key":"e_1_2_1_11_1","first-page":"167","article-title":"Fetal intestinal disaccharidases in human amniotic fluid","volume":"25","author":"Potier M.","year":"1976","journal-title":"Biomed"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0016-5085(77)80031-0","article-title":"Developmental pattern of small intestinal enterokinase and disaccharidase activities in the human fetus","volume":"72","author":"Antonowicz I.","year":"1977","journal-title":"Gastroenterology"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.22.4.429"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.5.402"},{"issue":"4","key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1542\/peds.66.4.556","article-title":"Development of functional response in human exocrine pancreas","volume":"66","author":"Lebenthal E.","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_1_16_1","unstructured":"BokermannM. TrackN S. CreutzfeldtC. CreutzfeldtW.(1981)Biochemical and ultrastructural changes in the human pancreas during foetal development. Approaches to Cystic Fibrosis Research. Intern. 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