{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:45:31Z","timestamp":1761155131922},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":8776,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:p>Studies on the transfer of drugs from mother to fetus in the first trimester of pregnancy are important because of the possible teratogenic effect on the fetus as well as possible therapeutic effect on both sides of the feto\u2010maternal barrier. The purpose of this study was to measure drug concentrations in maternal plasma, placental tissue and amniotic fluid in a group of first\u2010trimester abortion patients. Ceftazidime and thiopental were chosen as experimental drugs. The analyses were done with high pressure liquid chromatography. The penetration of ceftacidime into placental tissue and amniotic fluid was 20.6 and 2.2% from 1 to 4 h after drug administration. The corresponding values for thiopental were 54.3\u201371 and 1.5\u20137.4% from 5 to 15 min after drug administration, indicating a rapid transfer of both drugs across the feto\u2010maternal barrier during this period in pregnancy.<\/jats:p>","DOI":"10.3109\/00016348709092949","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T13:05:02Z","timestamp":1196168702000},"page":"29-33","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Concentrations of Ceftazidime and Thiopental in Maternal Plasma, Placental Tissue and Amniotic Fluid in Early Pregnancy"],"prefix":"10.1111","volume":"66","author":[{"given":"N. P.","family":"J\u00f8rgensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Walstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Molne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/8.suppl_B.187"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","DOI":"10.1093\/jac\/8.suppl_B.23","article-title":"Ceftazidime: in\u2010vitro antibacterial activity and susceptibility to \u03b2\u2010lactamases compared with that of cefotaxime, moxalactam and other \u03b2\u2010lactam antibiotics","volume":"8","author":"Phillips I.","year":"1981","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_1_4_1","first-page":"39","volume-title":"Laboratory and clinical experience with ceftacidime","author":"Walstad R A.","year":"1985"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/52.9.913"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/8.suppl_B.227"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348409155554"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01061846"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347309158319"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","unstructured":"BerganT..Pharmacokinetics and tissue penetration of antibiotics Rev Infect Dis.1981;3:45\u201366.","DOI":"10.1093\/clinids\/3.1.45"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.suppl_A.275"},{"volume-title":"Modern Pharmacology","year":"1982","author":"Craig C R.","key":"e_1_2_1_12_1"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016348709092949","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016348709092949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T19:24:03Z","timestamp":1697916243000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016348709092949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.3109\/00016348709092949"],"URL":"https:\/\/doi.org\/10.3109\/00016348709092949","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"type":"print","value":"0001-6349"},{"type":"electronic","value":"1600-0412"}],"subject":[],"published":{"date-parts":[[1987,1]]},"assertion":[{"value":"2011-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}