{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T01:14:53Z","timestamp":1774746893755,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":8411,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:p><jats:bold>Abstract.<\/jats:bold>In a double\u2010blind, randomized trial, the antithrombotic effect and haemorrhagic complications of low molecular weight heparin (LMWH) (Heparin fragment 2165, KabiVitrum) and unfractionated heparin (UH) were compared. LMWH (5000 anti\u2010XaU) was injected every 24 h, UH (5000 IU) every 12 h; both drugs by subcutaneous injection. During 1984\u201385, 215 patients were examined clinically and by plethysmography. Venography was performed whenever DVT was suspected. None of the patients proved to have DVT. Bleeding complications were found in 54% of the cases. The LMWH group had a statisticaly significant predominance of bleeding complications as reflected by wound haematomas (p = 0.02) and the number of blood transfusions (p = 0.02). The heparin concentration was higher in the LMWH group (mean 0.13 IU\/ml) than in the UH group (mean 0.13 IU\/ml) measured 2 h after the injection. In the doses administered, LMWH and UH seem effective in the prevention of thrombosis. The increased bleeding tendency in the LMWH group probably was a concequence of the to high dosage.<\/jats:p>","DOI":"10.3109\/00016348809004178","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:05:44Z","timestamp":1194980744000},"page":"99-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Comparison of Low Molecular Weight Heparin vs. Unfractionated Heparin in Gynecological Surgery"],"prefix":"10.1111","volume":"67","author":[{"given":"E.","family":"Borstad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Urdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Handeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Abildgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"486","article-title":"Low dose heparin in prevention of deep venous thrombosis after gynecological surgery","volume":"81","author":"Ballard R M.","year":"1973","journal-title":"J Obstet Gyn Br Commonw"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(83)90091-9"},{"key":"e_1_2_1_4_1","first-page":"184","article-title":"Pharmacokinetics of a low molecular weight heparin as compared with conventional heparin in humans","volume":"50","author":"Bratt D.","year":"1983","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V59.6.1239.1239"},{"issue":"36","key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-0609.1980.tb02513.x","article-title":"Kinetics in normal humans of anticoagulant activity, radioactivity and lipolytic activity after intravenous addministration of (S35) heparin and (S35) fractions","volume":"25","author":"Swart C AM","year":"1980","journal-title":"Scand J Haematol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb09307.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1879-3479.1976.tb00559.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(82)90089-5"},{"key":"e_1_2_1_10_1","first-page":"567","article-title":"Prevention of fatal postoperative pulmonary embolism by low dosis of heparin. Reappraisal of results","author":"Kakkar V V.","year":"1977","journal-title":"Lancet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1974.tb00503.x"},{"issue":"64","key":"e_1_2_1_12_1","first-page":"69","article-title":"Effect of heparin and heparin fractions on platelet aggregation","volume":"65","author":"Salzmann E W.","year":"1980","journal-title":"J Clin Invest"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1036983"},{"issue":"5","key":"e_1_2_1_14_1","first-page":"321","article-title":"Plethysmografisk diagnostikk av dyp venetrombose","volume":"102","author":"Stranden E.","year":"1982","journal-title":"Tidssk Nor Laegefor"},{"key":"e_1_2_1_15_1","first-page":"669","article-title":"Prevention of post\u2010operative deep venous thrombosis with perioperative subcutaneous heparin","author":"Williams H T.","year":"1971","journal-title":"Lancet"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016348809004178","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016348809004178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:22:15Z","timestamp":1708302135000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016348809004178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.3109\/00016348809004178"],"URL":"https:\/\/doi.org\/10.3109\/00016348809004178","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]},"assertion":[{"value":"2011-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}