{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:12:25Z","timestamp":1774923145713,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":8411,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> A treatment with the GnRH\u2010agonist, buserelin, was given intranasally in a dosage of 400 g once daily, to induce anovulation in 26 women with premenstrual tension syndrome; 23 patients completed the study course. The design was double\u2010blind and crossover. Daily symptom ratings were made for two pretreatment, diagnostic cycles and continued for up to six cycles or 6 months. The rating scale used was an earlier described visual analogue scale. Blood samples for estradiol and progesterone radio\u2010immunoassay were taken once weekly throughout the study. Results show beneficial effects of both placebo and GnRH\u2010agonist, compared with the pretreatment situation. The GnRH\u2010agonist was, however, significantly better than placebo. At the end of the treatment periods the patients while still taking placebo, still showed cyclical symptom changes, whereas during the GnRH\u2010agonist treatment the cyclical changes had disappeared. The results indicate that a factor from the corpus luteum must be involved in the etiology of cyclical mood changes. The results also show that inhibition of ovulation by mean of GnRH\u2010agonists is one possible way to treat premenstrual tension syndrome.<\/jats:p>","DOI":"10.3109\/00016348809004191","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:05:52Z","timestamp":1194980752000},"page":"159-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Induced Anovulation As Treatment Of Premenstrual Tension Syndrome: A double\u2010blind cross\u2010over study with GnRH\u2010agonist versus placebo"],"prefix":"10.1111","volume":"67","author":[{"given":"Stefan","family":"Hammarb\u00e4ck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f6rn","family":"B\u00e4ckstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1931.02230110151009"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-198312000-00004"},{"key":"e_1_2_1_4_1","first-page":"539","article-title":"Premenstrual complaints. 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