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The relative distributions of dermatan sulphate, heparan sulphate, hyaluronic acid and chondroitin sulphate were measured after cellulose acetate electrophoresis. Mammary tissue samples were obtained at the time of surgery from 11 women, 6 with fibroadenomata and 5 with carcinoma. From each patient, biopsies were obtained centrally in the tumor and perilesional areas adjacent to the tumor, and also from clinically uninvolved tissue in the same region. In the central areas, it was found that carcinoma had a significant increase in chondroitin sulphate and uronic acid content, and a significant decrease in dermatan sulphate content, as compared with fibroadenoma. The chondroitin sulphate content in perilesional carcinomatous tissue was significantly greater than in clinically uninvolved tissue.<\/jats:p>","DOI":"10.3109\/00016348809029866","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:44:56Z","timestamp":1195692296000},"page":"539-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Glycosaminoglycans in human breast cancer"],"prefix":"10.1111","volume":"67","author":[{"given":"Elith Bjarne","family":"Olsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Trier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Eldov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorkil","family":"Ammitzb\u00f8ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"39","volume-title":"Cell Biology of Extracellular Matrix","author":"Hascall V C.","year":"1982"},{"key":"e_1_2_1_3_1","first-page":"259","volume-title":"Cell Biology of Extracellular Matrix","author":"Toole B P.","year":"1982"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.88.3.473"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90548-6"},{"key":"e_1_2_1_6_1","first-page":"4717","article-title":"Intercellular glycosaminoglycans in normal and neoplastic tissues","volume":"38","author":"Chiarugi V P.","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(77)91046-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810701)48:1<89::AID-CNCR2820480118>3.0.CO;2-B"},{"key":"e_1_2_1_9_1","first-page":"124","article-title":"Proteoglycan changes in the intercellular matrix of human colon carcinoma","volume":"47","author":"Iozzo R V.","year":"1982","journal-title":"Lab Invest"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(73)90377-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(79)80012-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811101)48:9<2016::AID-CNCR2820480918>3.0.CO;2-A"},{"key":"e_1_2_1_13_1","first-page":"2133","article-title":"Variation in glycosaminoglycan components of breast tumors","volume":"36","author":"Takeuchi J.","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_1","first-page":"164","article-title":"Glycosaminoglycans in human breast cancer: morphological and biochemical study","volume":"3","author":"Marotta M.","year":"1985","journal-title":"Appl Pathol"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016348809029866","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016348809029866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T19:34:21Z","timestamp":1697916861000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016348809029866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.3109\/00016348809029866"],"URL":"https:\/\/doi.org\/10.3109\/00016348809029866","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]},"assertion":[{"value":"2011-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}