{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:44:55Z","timestamp":1774611895198,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T00:00:00Z","timestamp":1294704000000},"content-version":"vor","delay-in-days":8045,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:p>A series of 119 women with Human papillomavirus (HPV) infections of the uterine cervix and\/or vagina were included in the present study, where the efficacy of cryotherapy and CO<jats:sub>2<\/jats:sub>\u2010laser vaporization was assessed after a mean follow\u2010up of 14 months (SD 6 months) after treatment, as related to the natural history of the disease. Routine Papanicolaou (PAP) smears with HPV\u2010induced changes were the basis for patient recruitment. Patients with cervical HPV lesions (HPV\u2010NCIN, HPV\u2010CIN l or II) were randomly allocated into laser (55 women) and cryotherapy (42 women) groups. Women with combined lesions (HPV\u2010CIN &amp; HPV\u2010VAIN) were treated by laser (22 patients). The cure rate after laser vaporization was practically identical to that of cryotherapy, 64% and 54%, respectively (difference not statistically significant). The success rate was significantly lower (40%) for the combined lesions (HPV\u2010CIN &amp; HPV\u2010VAIN)(p&lt;0.05). The residual disease encountered in patients after the first treatment with cryotherapy and laser was classified as HPV\u2010NCIN in 78.9% and 37.0%, respectively. The number of patients is still too small to draw reliable conclusions on the effects of these therapy modes, as related to HPV type of lesion (HPV 6, 11, 16, 18, 31 and 33). The cure rates for both cryotherapy and laser in our treatment groups were significantly higher than the spontaneous regression rate (p &lt; 0.001), suggesting that treatment by either cryotherapy or CO<jats:sup>2<\/jats:sup>,\u2010laser vaporization significantly changes the natural history of genital HPV infections. More patients and longer follow\u2010up are still needed, however, to fully establish the efficacy of the current treatment modalities in gynecological HPV infections.<\/jats:p>","DOI":"10.3109\/00016348909013281","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:06:59Z","timestamp":1194980819000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cryotherapy and Co<sub>2<\/sub>\u2010Laser Vaporization in the Treatment of Cervical and Vaginal Human Papillomavirus (HPV) Infections"],"prefix":"10.1111","volume":"68","author":[{"given":"Merja","family":"Yliskoski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Saarikoski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stina","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli","family":"Castr\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"720","article-title":"Treatment of cervical intraepithelial neoplasia with the carbon dioxide laser: Report of 543 patients","volume":"59","author":"Anderson M C.","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_3_1","first-page":"378","article-title":"Management of cervical intraepithelial neoplasia by carbon dioxide laser","volume":"60","author":"Baggish M S.","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_4_1","first-page":"147","article-title":"Colposcopy and the CO laser for treatment of cervical intraepithelial neoplasia","volume":"28","author":"Bellina J H.","year":"1983","journal-title":"J Reprod Med"},{"key":"e_1_2_1_5_1","first-page":"725","article-title":"Cryotherapy in the treatment of cervical intraepithelial neoplasia","volume":"58","author":"Benedet J L.","year":"1981","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_6_1","first-page":"188","article-title":"Efficacy of cryotherapy in the treatment of human papilloma virus infection of the uterine cervix","volume":"73","author":"Benrubi G.","year":"1986","journal-title":"J Florida M A"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90587-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198009000-00001"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1979.tb11238.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(84)90214-2"},{"key":"e_1_2_1_11_1","first-page":"793","article-title":"Comparison of cryo\u2010 and carbon dioxide laser therapy for cervical intraepithelial neoplasia","volume":"66","author":"Ferenczy A.","year":"1985","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/jid.1984.16","article-title":"Presence of human papillomavirus in genital tumors","volume":"83","author":"Gissmann L.","year":"1984","journal-title":"J Invest Dermatol"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90411-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901015)60:8 <1942::AID-CNCR2820601504>3.0.CO;2-V"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(85)90003-4"},{"key":"e_1_2_1_16_1","first-page":"1","article-title":"Conization for preinvasive and early cervical carcinoma of the uterine cervix","volume":"114","author":"Larsson G.","year":"1983","journal-title":"Acta Obstet Gynecol Scand"},{"key":"e_1_2_1_17_1","first-page":"505","article-title":"Condylomatous lesions of cervix and vagina. 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