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The following parameters were measured: whole blood clotting time (WBCT), whole blood clot lysis time, fibrinogen, antithrombin III, factors V, VII and VIII. Blood samples were taken before treatment and in cycles 1, 3 and 6. A significant shortening of WBCT was observed in cycle 3 and 6 in both groups and also in cycle 1 in the gestodene group. This may indicate an increased sensitivity for activation of platelets, since the assay appears to be quite sensitive to this process. In the other parameters tested there were no significant changes except for a slight increase in plasma fibrinogen in cycle 1 in the gestodene group.<\/jats:p>","DOI":"10.3109\/00016348909087684","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T13:05:14Z","timestamp":1196168714000},"page":"27-30","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects Of Two Triphasic Oral Contraceptives Containing Ethinylestradiol Plus Levonorgestrel Or Gestodene On Blood Coagulation And Fibrinolysis"],"prefix":"10.1111","volume":"68","author":[{"given":"Ivar H.","family":"Omsj\u00f8","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l","family":"\u00f8ian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Martin","family":"Maltau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjarne","family":"\u00f8sterud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5703.203"},{"issue":"6","key":"e_1_2_1_3_1","first-page":"1","article-title":"Female hormones and vascular disease: An epidemiological overview","author":"Vessey M P.","year":"1980","journal-title":"Br J Fam Plann"},{"key":"e_1_2_1_4_1","first-page":"85","article-title":"Haemostatic system changes induced by 50 \u03bcg and 30 \u03bcg estrogen\/progestogen oral contraceptives","volume":"28","author":"Sabra A.","year":"1983","journal-title":"J Reprod Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91550-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-6675-1_10"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-5930-2_7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(83)90246-3"},{"key":"e_1_2_1_9_1","first-page":"226","article-title":"Sodium acetate buffer. 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