{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:23:28Z","timestamp":1783686208247,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To compare the success rates of single and multiple dose methotrexate protocols for the treatment of unruptured tubal ectopic pregnancy. <jats:italic>Design.<\/jats:italic> Prospective randomized controlled trial. <jats:italic>Setting.<\/jats:italic> Maternity and teaching hospital in Turkey. <jats:italic>Population.<\/jats:italic> One hundred twenty women treated with methotrexate therapy for unruptured tubal ectopic pregnancy. <jats:italic>Methods.<\/jats:italic> Sixty\u2010two women received a single dose and 58 received a multiple dose methotrexate regimen. <jats:italic>Main outcome measures.<\/jats:italic> Success rate of methotrexate therapy (women successfully treated with one injection and women who completed four doses). <jats:italic>Results.<\/jats:italic> In the single dose group, treatment was considered successful in 50 women (80.6%), whereas in the multiple dose group, 52 women (89.7%) responded to treatment (<jats:italic>p<\/jats:italic> = 0.21; OR 0.90, 95%CI 0.77\u20131.05). The average number of days required for human chorionic gonadotropin (hCG) levels to fall below 5 mU\/mL was longer in the single dose (22.3 \u00b1 7.6) compared with the multiple dose group (18.3 \u00b1 10.7) (<jats:italic>p<\/jats:italic> = 0.03). In the single dose group fewer or 17 women (24.7%) experienced side\u2010effects compared to 28 (48.3%) of those who had multiple doses (<jats:italic>p<\/jats:italic> = 0.02, OR 0.57, 95%CI 0.35\u20130.92). <jats:italic>Conclusion.<\/jats:italic> A multiple dose methotrexate regimen for the treatment of unruptured tubal ectopic pregnancy is not more effective than a single dose one. In addition, multiple doses may cause more side\u2010effects, but the time for hCG levels to fall below 5 mU\/mL is shorter.<\/jats:p>","DOI":"10.3109\/00016349.2010.486825","type":"journal-article","created":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T07:21:28Z","timestamp":1277796088000},"page":"889-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Comparison of single and multiple dose methotrexate therapy for unruptured tubal ectopic pregnancy: a prospective randomized study"],"prefix":"10.1111","volume":"89","author":[{"given":"EMINE SEDA","family":"GUVENDAG 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