{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:51:26Z","timestamp":1794325886427,"version":"4.9.0"},"reference-count":85,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To systematically review the risks of pregnancy outcomes among women of different parity. <jats:italic>Material and methods.<\/jats:italic> Electronic databases were searched for studies, in English language, in which primary objective was to assess association between parity and pregnancy outcomes. Meta\u2010analyses were performed and unadjusted odds ratios (ORs) and mean differences along with 95% confidence interval (CI) were calculated. <jats:italic>Main outcome measures.<\/jats:italic> Low birth weight (LBW), preterm birth (PTB), small for gestational age (SGA), birth weight, and gestational age. <jats:italic>Results.<\/jats:italic> Forty\u2010one studies, most with moderate risk of bias were included. Nulliparity was associated with increased unadjusted odds of LBW (OR 1.41, 95% CI 1.26, 1.58) and SGA (OR 1.89, 95% CI 1.82, 1.96) and reduction in birth weight (weighted mean difference \u2212282 g, 95% CI \u2212486, \u221279 g) but not PTB (OR 1.13, 95% CI 0.96, 1.34). Grand multiparity and great grand multiparity were not associated with LBW (OR 1.10, 95% CI 0.95, 1.32 and OR 0.92, 95% CI 0.78, 1.09) or PTB (OR 0.96, 95% CI 0.77, 1.19 and OR 1.32, 95% CI 0.61, 2.83). <jats:italic>Conclusions.<\/jats:italic> Nulliparity was associated with a significantly increased unadjusted risk of LBW\/SGA birth, whereas grand multiparity and great grand multiparity were not associated with increased risk of pregnancy outcomes.<\/jats:p>","DOI":"10.3109\/00016349.2010.486827","type":"journal-article","created":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T07:21:28Z","timestamp":1277796088000},"page":"862-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":267,"title":["Parity and low birth weight and preterm birth: a systematic review and meta\u2010analyses"],"prefix":"10.1111","volume":"89","author":[{"given":"PRAKESH S.","family":"SHAH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of Knowledge Synthesis Group on Determinants of LBW\/PT births","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706475"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0730-7659.2005.00344.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)90086-2"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016340903358820"},{"key":"e_1_2_7_7_2","unstructured":"HigginsPT GreenS.Cochrane handbook for systematic reviews of interventions.The Cochrane Collaboration2008[cited 2008 March 1]; (Version 5.0.0). Available online at:http:\/\/www.cochrane\u2010handbook.org."},{"key":"e_1_2_7_8_2","unstructured":"UNDP.New UN data shows progress in human development. Human Development Report Office 18122 [cited 2009 July 20]. Available online at:http:\/\/hdr.undp.org\/en\/mediacentre\/news\/title 15493 en.html."},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701451386"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70511-9"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(92)90152-O"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01058.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1970.tb03493.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1977.tb76717.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(84)90110-5"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90161-5"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000293273"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(93)90148-P"},{"key":"e_1_2_7_20_2","first-page":"468","article-title":"Maternal age, parity and gestational age on the size of the newborn in Addis Ababa","volume":"76","author":"Feleke Y","year":"1999","journal-title":"East Afr Med J"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01283.x"},{"key":"e_1_2_7_22_2","first-page":"142","article-title":"Data for quantitative genetics in man; birth weight in official statistics","volume":"30","author":"Fraccaro M","year":"1958","journal-title":"Hum Biol"},{"key":"e_1_2_7_23_2","first-page":"719","article-title":"The problem of the \u201cgrand multipara\u201d. A review of 1677 cases","volume":"18","author":"Fuchs K","year":"1961","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_24_2","first-page":"99","article-title":"Association of maternal age and parity with birth weight, sex ratio, stillbirths and multiple births","volume":"22","author":"Gebre\u2010Medhin M","year":"1976","journal-title":"J Trop Pediatr Environ Child Health"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(95)02108-J"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(94)90168-6"},{"key":"e_1_2_7_27_2","first-page":"1503","article-title":"Grand multipara","volume":"111","author":"Kjer JJ","year":"1989","journal-title":"Zentralbl Gynakol"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00498-5"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00152-3"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(88)90329-3"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1959.tb01463.x"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(58)90711-7"},{"key":"e_1_2_7_33_2","first-page":"52","article-title":"Is granmultiparity a significant risk factor in this new millenium?","volume":"13","author":"Nordin NM","year":"2006","journal-title":"Malays J Med Sci"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/32.6.295"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(92)90326-E"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1973.tb08151.x"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000127426.95464.85"},{"key":"e_1_2_7_38_2","first-page":"690","article-title":"High parity in the Negro parturient","volume":"38","author":"Roopnarinesingh S","year":"1971","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_39_2","first-page":"625","article-title":"Grand multiparitya nationwide survey","volume":"25","author":"Samueloff A","year":"1989","journal-title":"Isr J Med Sci"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(87)90176-7"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90213-X"},{"key":"e_1_2_7_42_2","first-page":"501","article-title":"The relationship between parental age and birth order with the percentage of low birth\u2010weight infants","volume":"44","author":"Selvin S","year":"1972","journal-title":"Hum Biol"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02389543"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1991.tb00282.x"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016348709092954"},{"key":"e_1_2_7_46_2","first-page":"41","article-title":"Grand multiparity: a study of 168 cases","volume":"24","author":"Tessarolo M","year":"1997","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90593-6"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609033354"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500123798"},{"key":"e_1_2_7_50_2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0002-9378(16)35787-8","article-title":"Grand multiparity\u2013its obstetric implications","volume":"84","author":"Ziel HA","year":"1962","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.3109\/01443618709008776"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1989.tb00170.x"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.119639"},{"key":"e_1_2_7_54_2","first-page":"45","article-title":"Grand multiparity in Singapore women","volume":"15","author":"Dawood MY","year":"1974","journal-title":"Singapore Med J"},{"key":"e_1_2_7_55_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.5694\/j.1326-5377.2004.tb05871.x","article-title":"Is grand multiparity an independent predictor of pregnancy risk? A retrospective observational study [comment]","volume":"180","author":"de Costa CM","year":"2004","journal-title":"Med J Aust"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0456"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2003.tb05550.x"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1969.tb00094.x"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.3109\/01443618609112276"},{"key":"e_1_2_7_60_2","first-page":"150","article-title":"Hazards of grand multiparity","volume":"5","author":"Oxoen H","year":"1955","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_61_2","first-page":"451","article-title":"Maternal death rates and incidence of abnormalities in women of parity 6 or more","volume":"23","author":"Quinlivan WL","year":"1964","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_62_2","first-page":"9","article-title":"Do gravidity and age affect pregnancy outcome?","volume":"36","author":"Santow G","year":"1989","journal-title":"Social Biol"},{"key":"e_1_2_7_63_2","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S0002-9378(16)35788-X","article-title":"The grand multipara. A survey of 403 cases","volume":"84","author":"Schrafman E","year":"1962","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(54)90116-7"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1341-8076.2002.00025.x"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6143.1001"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00269-X"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(95)02417-B"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(91)90171-Z"},{"key":"e_1_2_7_70_2","first-page":"433","article-title":"Grand multiparity; survey and appraisal","volume":"7","author":"Krebs JM","year":"1956","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.3109\/01443619209015511"},{"key":"e_1_2_7_72_2","first-page":"443","article-title":"Pregnancy order. A factor influencing birth weight in twin gestations","volume":"40","author":"Blickstein I","year":"1995","journal-title":"J Reprod Med"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.11.009"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1999.0536"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)31096-9"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000128905.37143.47"},{"key":"e_1_2_7_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.121"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-536X.1992.tb00368.x"},{"key":"e_1_2_7_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/5.2.131"},{"key":"e_1_2_7_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02391578"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349709024342"},{"key":"e_1_2_7_82_2","first-page":"234","article-title":"Birth weight, maternal age, and parity among the African population of Uganda","volume":"22","author":"Simpkiss MJ","year":"1968","journal-title":"Br J Prev Soc Med"},{"key":"e_1_2_7_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01855.x"},{"key":"e_1_2_7_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115088"},{"key":"e_1_2_7_85_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470020063033"},{"key":"e_1_2_7_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(65)90246-2"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349.2010.486827","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349.2010.486827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T13:30:38Z","timestamp":1697376638000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349.2010.486827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":85,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.3109\/00016349.2010.486827"],"URL":"https:\/\/doi.org\/10.3109\/00016349.2010.486827","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}