{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:01:41Z","timestamp":1789948901576,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":121,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. Pre\u2010eclampsia shares several similarities with atherosclerotic heart disease. We explored whether, like atherosclerosis, there is a potential link between cytomegalovirus (CMV) infection and pre\u2010eclampsia. <jats:italic>Design<\/jats:italic>. CMV IgG, IgM and IgA antibodies were determined by enzyme\u2010linked immunosorbent assays in serums from pre\u2010eclampsia (<jats:italic>n<\/jats:italic> = 78), normotensive intrauterine growth restriction (nIUGR) (<jats:italic>n<\/jats:italic> = 30) and normal pregnancy controls (<jats:italic>n<\/jats:italic> = 109). Data were analyzed by chi\u2010squared, Kruskal\u2013Wallis ANOVA and Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010tests. Further, we conducted a comprehensive review of published studies on the relation between CMV infection and pre\u2010eclampsia. Risk ratios (RRs) and 95% confidence interval (CI), according to CMV infection status, were calculated using Review Manager. <jats:italic>Main outcome measures<\/jats:italic>. Women with pre\u2010eclampsia had increased CMV IgG seropositivity compared with nIUGR (<jats:italic>p<\/jats:italic> &lt; 0.01) and normal pregnancy controls (<jats:italic>p<\/jats:italic> &lt; 0.01). In addition, CMV IgG antibody level was higher in pre\u2010eclampsia than normal pregnancy controls (<jats:italic>p<\/jats:italic> &lt; 0.001). No difference was observed in CMV IgM or IgA among study groups. Data synthesis revealed that women with CMV infection were at higher risk in the development of pre\u2010eclampsia, compared with women without CMV infection. Combined results for six studies yielded a RR of 1.5 (95% CI 1.2\u20131.9). <jats:italic>Conclusion<\/jats:italic>. CMV infection seems to affect the occurrence of pre\u2010eclampsia. Evaluation of the relation between CMV infection and pre\u2010eclampsia may provide mechanistic insights into pre\u2010eclampsia\u2010related inflammation.<\/jats:p>","DOI":"10.3109\/00016349.2010.499449","type":"journal-article","created":{"date-parts":[[2010,8,30]],"date-time":"2010-08-30T13:39:43Z","timestamp":1283175583000},"page":"1162-1167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["An association between cytomegalovirus infection and pre\u2010eclampsia: a case\u2013control study and data synthesis"],"prefix":"10.1111","volume":"89","author":[{"given":"Fang","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura 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