{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:56:08Z","timestamp":1790978168966,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T00:00:00Z","timestamp":1294185600000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. We examined the influence of the androgen receptor gene (AR) CAG microsatellite (AR<jats:italic>\u2010<\/jats:italic>CAG) repeat polymorphism and X\u2010chromosome inactivation (XCI) pattern on ovarian reserve markers (follicle stimulating hormone (FSH) and antral follicle count on menstrual cycle day 3\u20135) and disease etiology in patients with polycystic ovarian syndrome (PCOS) or premature ovarian failure (POF). <jats:italic>Design<\/jats:italic>. Case\u2010control study. <jats:italic>Population<\/jats:italic>. In all, 32 women with PCOS, 26 women with POF and 79 controls were investigated. <jats:italic>Methods<\/jats:italic>. AR<jats:italic>\u2010<\/jats:italic>CAG and XCI were analyzed using polymerase chain reaction\u2010based assays following DNA digestion with the methylation\u2010sensitive restrictase <jats:italic>Hpa<\/jats:italic>II. <jats:italic>Main outcome measures<\/jats:italic>. Distribution of AR\u2010CAG alleles and XCI patterns. <jats:italic>Results<\/jats:italic>. POF patients had shorter AR<jats:italic>\u2010<\/jats:italic>CAG microsatellites than controls. AR<jats:italic>\u2010<\/jats:italic>CAG microsatellite length was negatively associated with serum dehydroepiandrosterone sulfate level. The magnitude of XCI skewing was negatively and positively correlated with luteinizing hormone (LH) and FSH serum levels, respectively, during the early follicular phase, but showed no correlation with the number of early antral follicles. <jats:italic>Conclusions<\/jats:italic>. Our results suggest that AR<jats:italic>\u2010<\/jats:italic>CAG variations and XCI pattern exert an effect on FSH and LH values, and also have the potential to influence the etiopathogenesis of POF.<\/jats:p>","DOI":"10.3109\/00016349.2010.526182","type":"journal-article","created":{"date-parts":[[2010,11,5]],"date-time":"2010-11-05T10:03:19Z","timestamp":1288951399000},"page":"1557-1563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Androgen receptor epigenetic variations influence early follicular phase gonadotropin levels"],"prefix":"10.1111","volume":"89","author":[{"given":"Triin","family":"Laisk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadri","family":"Haller\u2010Kikkatalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Laanpere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dclle","family":"Jakovlev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maire","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Karro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Salumets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57782-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56875-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107979"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000233937.36554.d3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986706776872943"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80057-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509283331307"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmh010"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.15.3181"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801293380611"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.7.1217"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2007.00782.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.11.085"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.5.8404672"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30256"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem415"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31312"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513591003632217"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/jcem.87.1.8137","article-title":"The androgen receptor CAG repeat polymorphism and X\u2010chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome","volume":"87","author":"Hickey T","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.9.3484"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0069"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1047"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1424"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007428200"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220929"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.10.059"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1735"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70076-1"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349.2010.526182","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349.2010.526182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:34:52Z","timestamp":1697430892000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349.2010.526182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.3109\/00016349.2010.526182"],"URL":"https:\/\/doi.org\/10.3109\/00016349.2010.526182","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"2011-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}