{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:51Z","timestamp":1760188911039},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":7676,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>Milligram\u2010range doses of E<jats:sub>2<\/jats:sub> prostaglandins have long been used to induce labor or abortion in the second and third trimesters of pregnancy. Enprostil, a synthetic dehydroprostaglandin E<jats:sub>2<\/jats:sub> structural analogue, is administered in microgram doses for the treatment of acute duodenal ulcer and acute gastric ulcer. This study examined the effect of the ulcer\u2010healing dose and twice the ulcer\u2010healing dose upon women in the first trimester of pregnancy. Two hundred and seven women who had requested legal abortion in the first trimester participated in two randomized, double\u2010blind, placebo\u2010controlled, parallel studies. They received two doses of enprostil 35 \u03bcg (the recommended dose for the treatment of duodenal and gastric ulcer) (n=51), 70 \u03bcg (twice the recommended dose) (n=53), or placebo (n = 103) 12 h apart. No drug\u2010induced abortions occurred in any of the first\u2010trimester pregnancies. Vaginal bleeding occurred in 4% of volunteers receiving the lower dose and 4% receiving the higher dose of enprostil. Vaginal bleeding occurred in up to 2% of volunteers on placebo. Although not recommended for pregnant women, if enprostil is given inadvertently to pregnant women with ulcers, it is unlikely to endanger the pregnancy during the first trimester.<\/jats:p>","DOI":"10.3109\/00016349009006158","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:07:10Z","timestamp":1194980830000},"page":"135-138","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["No Abortion\u2010Inducing Effect of Tht Ulcer\u2010Healing Dosf the Synthetic Prostaglandin E<sub>2<\/sub> Analogue Enprostil In First Trimester"],"prefix":"10.1111","volume":"69","author":[{"given":"Jan","family":"Jacobson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Bergquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Rydnert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Bokstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Huovinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(86)80013-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(86)80014-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(86)80015-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(86)80016-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(86)80017-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.134"},{"key":"e_1_2_1_8_1","first-page":"54","article-title":"Preinduction cervical ripening with prostaglandin E2 intracervical gel","volume":"68","author":"Laube D W.","year":"1986","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(85)90039-3"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(86)90084-3"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0002-9378(75)90485-8","article-title":"Oral prostaglandin E2 for induction of labor at term: II. 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