{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:19:10Z","timestamp":1783487950084,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":7676,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>An open, randomized, multicenter study was carried out to compare two oral contraceptives as regards their therapeutic efficacy in androgenization symptoms such as acne, seborrhea and hirsutism in women. The preparations used were the combination of 2 mg cyproterone acetate (CPA) with 0.035 mg ethinyl estradiol (EE) (Diane35\u00ae, Schering AG, Berlin\u2010West) and 0.150 mg desogestrel (DG) with 0.03 mg ethinyl estradiol (Marvelon\u00ae, Organon, Oss, The Netherlands).<\/jats:p><jats:p>The duration of therapy was 9 months. The combination of CPA\u2010EE was used by 83 patients for 658 cycles and the combination of DG\u2010EE by 79 women for 618 cycles. No pregnancy occurred under either therapy. Both preparations are well tolerated. However, some side\u2010effects, such as reduced libido, nervousness and breast tenderness, were observed more frequently (p &lt; 0.05) in the DG\u2010EE group than among the users of the CPA\u2010EE Combination. The therapeutic outcome was better in the CPA\u2010EE group, especially in cases of facial acne (p&lt;0.05). Seborrheic symptoms also responded better to the CPA\u2010EE therapy.<\/jats:p><jats:p>The results show that the CPA\u2010EE combination is superior to the DG\u2010EE combination in the treatment of acne and seborrhoea.<\/jats:p>","DOI":"10.3109\/00016349009021041","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:45:25Z","timestamp":1195692325000},"page":"61-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Ovulatlon Inhibitors Containing Cyproterone Acetate Or Desogestrel In The Treatment Of Hyperandrogenic Symptoms"],"prefix":"10.1111","volume":"69","author":[{"given":"R.","family":"Erkkola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hirvonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Luikku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lumme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"M\u00e4nnikk\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Avdinlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"425","article-title":"Diane\u2014eine Gestagen\u2010Ostrogen Kombination mit Antiandrogenwirkung","volume":"31","author":"Aydinlik S.","year":"1977","journal-title":"Med. Mschr."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6504.1231"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb04880.x"},{"key":"e_1_2_1_5_1","first-page":"590","volume-title":"Recent Resarch on Gynaecological Endocrinology","author":"Fugire P.","year":"1988"},{"key":"e_1_2_1_6_1","first-page":"547","article-title":"\u00d6strogen\u2010reduzierter Ovulationshemmer zur Aknetherapie","author":"Aydinlik S.","year":"1986","journal-title":"Fortschr. der Med."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348609157049"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1035954"},{"key":"e_1_2_1_9_1","first-page":"23","volume-title":"New Devel Biosciences 3","author":"Neumann F.","year":"1987"},{"key":"e_1_2_1_10_1","first-page":"13","volume-title":"Contraception in to the next decade. A preview to the year 2000","author":"Rekers H.","year":"1988"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2340\/0001555564517523","article-title":"Serum total and unbound testosterone and sex hormone binding globulin (SHBG) in female acne patients treated with two different oral contraceptives. Acta Derm","volume":"64","author":"Palatsi R.","year":"1984","journal-title":"Venereol"},{"issue":"11","key":"e_1_2_1_12_1","article-title":"Clinical evaluation of a monophasic Ethinylestradiol\/Desogestrel\u2014containing oral contraceptive","volume":"38","author":"Bilotta P.","year":"1988","journal-title":"Arzneirn.-Forschung\/Drug Research"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(86)90156-6"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1515\/9783110866902-009","volume-title":"Antiandrogen\u2010Estrogen therapy for signs of androgenization. New Devel Biosciences 3","author":"Falsetti L.","year":"1987"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-96246-2","volume-title":"Acne. Morphogenesis and treatment","author":"Plewig\u2010Kligman","year":"1975"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12676781"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349009021041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349009021041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:20:06Z","timestamp":1697998806000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349009021041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.3109\/00016349009021041"],"URL":"https:\/\/doi.org\/10.3109\/00016349009021041","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}