{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:20:15Z","timestamp":1789579215258,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":7676,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>Depressed pregnancy\u2010associated plasma protein A (PAPP\u2010A) concentrations have been found in patients with threatened abortion, often weeks before spontaneous abortion while the fetus was still alive. In order to extend these findings we have developed a highly sensitive PAPP\u2010A radio\u2010immunoassay and have established a reference range in early pregnancy for PAPP\u2010A between week 7 and week 20 of pregnancy, based on blood samples from 240 pregnant women. The gestational age was determined by ultrasound.<\/jats:p><jats:p>PAPP\u2010A was measured in 128 women admitted to hospital because of vaginal bleeding in the 7th to 20th gestational week. The viability of the fetus was confirmed by ultrasonography. The serum values of PAPP\u2010A were significantly lower (p = 0.002) in the group of women with vaginal bleeding than in the group of normally pregnant women. However, with regard to abortion later on, the predictive value of an abnormal blood test on admission was only 18.7%. Serial determinations showed increased PAPP\u2010A values corresponding to the centile expected in the 12 women who aborted, as well as in the 116 women who gave birth. Consequently, the test is of no clinical value in the assessment of the prognosis in patients with symptoms of threatened abortion.<\/jats:p>","DOI":"10.3109\/00016349009028701","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:07:44Z","timestamp":1194980864000},"page":"589-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Can Pregnancy\u2010Associated Plasma Protein A (Papp\u2010A) Predict the Outcome of Pregnancy in Women with Threatened Abortion and Confirmed Fetal Viability?"],"prefix":"10.1111","volume":"69","author":[{"given":"Susanne","family":"Ruge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Fog","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"S\u00f8Srensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aksel P.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(83)90047-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb08899.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1986.tb01530.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1984.tb05928.x"},{"key":"e_1_2_1_6_1","first-page":"233","article-title":"Comparison of serum and urine hCG levels with SP1 and PAPP\u2010A levels in patients with first\u2010trimeter vaginal bleeding","volume":"61","author":"Masson G M.","year":"1983","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(84)90075-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00006250-198003000-00011","article-title":"Threatened abortion studied by oestradiol\u201017\u03b2 in serum and ultrasound","volume":"55","author":"Hertz J B.","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_9_1","first-page":"42","article-title":"Early pregnancy failure: Study by ultrasonic and hormonal methods","volume":"55","author":"Jouppila P.","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_10_1","first-page":"223","article-title":"Diagnostic procedures in threatened abortion","volume":"64","author":"Hertz JB","year":"1984","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_11_1","first-page":"471","article-title":"Ultrasound signs in threatened abortion and their prognostic significance","author":"Mantoni M.","year":"1985","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)90341-1"},{"key":"e_1_2_1_13_1","first-page":"77","volume":"92","author":"Westergaard J G.","year":"1985","journal-title":"Does ultrasound examination render biochemical trests obsolete in the prediction of early pregnancy failure? 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