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Elastase\u2010like activity in pregnant women with imminent premature delivery (24\u201030 gestational weeks) was also high (78\u00b157). Elastase\u2010like activity of cervical mucus correlated with Bishop score in both normal term and preterm labor. Elastase\u2010containing granulocytes were identified by immunohistochemistry in ripened cervix in normal and preterm labor. Some granulocytes degranulate and release elastase into the cervical stroma. Others migrate through the basement membrane of the endocervix to reach the cervical canal. Elastase could not be demonstrated in immature cervix as assessed by Bishop score. The staining intensity of elastase in the cervix correlated closely with elastase\u2010like activity in cervical mucus. Thus elastase\u2010like activity in cervical mucus reflects the degree of cervical maturation. These results lead one to speculate that elastase is one of the neutral proteases which depolymerize and degrade collagen in the ripening cervix.<\/jats:p>","DOI":"10.3109\/00016349109006174","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:07:57Z","timestamp":1194980877000},"page":"29-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The relationship between granulocyte elastase\u2010like activity of cervical mucus and cervical maturation"],"prefix":"10.1111","volume":"70","author":[{"given":"Naohiro","family":"Kanayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Terao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90003-0"},{"key":"e_1_2_2_3_1","first-page":"195","volume-title":"Dilation of the cervix","author":"Veis A.","year":"1980"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(79)90020-6"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90248-3"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1850443"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)70234-8"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(84)90012-4"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109001"},{"key":"e_1_2_2_10_1","first-page":"1109","article-title":"Animal models of emphysema","volume":"117","author":"Karlinsky J B.","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_2_11_1","first-page":"1449","article-title":"Isolation and properties of oxidized alpha\u20101\u2010protease inhibitor from human rheumatoid synovial fluid","volume":"6","author":"Wong P S.","year":"1981","journal-title":"Biochem Biophys Res Commun"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198101223040402"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1988.tb00122.x"},{"key":"e_1_2_2_14_1","first-page":"506","volume-title":"Collagen in health and disease","author":"Woessner J F.","year":"1982"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408303110905"},{"key":"e_1_2_2_16_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0002-9378(79)90440-X","article-title":"Changes in the glycosaminoglycans distribution pattern in the human uterine cervix during pregnancy and labor","volume":"135","author":"Maillot K.","year":"1979","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2030209"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349109006174","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349109006174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:46:32Z","timestamp":1698021992000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349109006174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.3109\/00016349109006174"],"URL":"https:\/\/doi.org\/10.3109\/00016349109006174","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}