{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:38:10Z","timestamp":1758123490697},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":7311,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:p>Results are presented of a Phase III international multicentre trial to study the effect of a new low\u2010dose oral contraceptive (OC) containing 20 \u03bcg ethinylestradiol and 150 \u03bcg desogestrel (Mercilon\u00ae) regarding efficacy, cycle control, blood pressure, and acceptability. Altogether 1,684 women from 12 European countries were included in the study. Four pregnancies occurred, 3 of them patient failures, one tablet failure. The overall Pearl Index was 0.20. The frequency of irregular bleeding was comparable to that recorded with other commonly used low\u2010dose OCs. No serious side effects occurred. The incidence of the most frequently reported subjective side effects \u2010 headache, nausea and breast tension \u2010 was already low after the first cycle of treatment and decreased to below pretreatment levels with continued use. There was a small increase in mean body weight, which was confined essentially to young women. The preparation did not affect the mean systolic or diastolic blood pressure.<\/jats:p><jats:p>This new preparation has thus proved to be an effective, safe and well\u2010accepted ultra low\u2010dose oral contraceptive.<\/jats:p>","DOI":"10.3109\/00016349109007167","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:08:40Z","timestamp":1194980920000},"page":"497-500","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Phase III clinical trial with a new oral contraceptive containing 150 \u03bcg desogestrel and 20 \u03bcg ethinylestradiol"],"prefix":"10.1111","volume":"70","author":[{"given":"Paul","family":"Lammers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique op","family":"ten Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91550-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/oxfordjournals.bmb.a071485","article-title":"Oral contraceptives, blood clotting and thrombosis","volume":"34","author":"Poller L.","year":"1978","journal-title":"Br Med Bull"},{"key":"e_1_2_1_4_1","first-page":"1133","article-title":"Haemostasis and oral contraception","volume":"11","author":"Bonnar J.","year":"1985","journal-title":"Contraception-fertilite-sexualite"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(79)90097-0"},{"key":"e_1_2_1_6_1","first-page":"86","article-title":"Effect of oral contraceptives on serum lipids and cardiovascular disease","volume":"11","author":"Fotherby K.","year":"1985","journal-title":"Br J Family Planning"},{"issue":"6","key":"e_1_2_1_7_1","first-page":"1","article-title":"Female hormones and vascular disease","author":"Vessey M P.","year":"1980","journal-title":"Br J Family Planning"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(82)90072-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1037266"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347609156450"},{"key":"e_1_2_1_11_1","first-page":"54","volume-title":"Update on triphasic oral contraception","author":"Upton V.","year":"1983"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/0002-9378(69)90142-2","article-title":"Incidence of side effects with contraceptive placebo","volume":"105","author":"Aznar\u2010Ramos R.","year":"1969","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)38469-2"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348709156494"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(87)90001-1"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(87)90025-4"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348709156493"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(84)90007-6"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349109007167","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349109007167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:35:23Z","timestamp":1698042923000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349109007167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.3109\/00016349109007167"],"URL":"https:\/\/doi.org\/10.3109\/00016349109007167","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}