{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:26:39Z","timestamp":1782289599709,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":7311,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:p>Intracervical application of prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) in a viscous gel was compared with conventional wax\u2010based PGE<jats:sub>2<\/jats:sub> vagitories (pessaries) for ripening of the cervix prior to induction of labor. A total of 226 healthy pregnant women at term were randomly allocated to receive intracervical gel with an effective dose of 0.5 mg (n = 116) or vagitories containing 2.5 mg PGE<jats:sub>2<\/jats:sub> (n = 110). All women had a modified cervical score of \u2264 4. The numbers of cases contributed by each of the three centers were similar. There was no significant difference in parity, gestational length, maternal characteristics, indications for induction or preinduction cervical scores between the treatment groups. The rate of spontaneous birth was 71% in the gel group, compared with 69% in the vagitory group. Successful treatment was defined as active labor within 24 h or a change in cervical dilatation allowing artificial rupture of the membranes with subsequent progressive labor. The success rate was not significantly different in the gel group (82%) compared with the vagitory group (80%). There were no differences in the frequency of fetal distress, outcome of labor, assisted delivery rates or maternal side effects. The cervical scores were not different at 12 and 24 h after application. Intracervical gel and intravaginal application of PGE2 were similar in their efficacy and safety for ripening of the cervix and inducing labor at term.<\/jats:p>","DOI":"10.3109\/00016349109007915","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:08:42Z","timestamp":1194980922000},"page":"549-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Open Randomized Comparison of Prostaglandin E<sub>2<\/sub> Given by Intracervical Gel or Vagitory for Preinduction Cervical Ripening and Induction of Labor"],"prefix":"10.1111","volume":"70","author":[{"given":"Henning Kvist","family":"Poulsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Krag","family":"Moller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes G.","family":"Westergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten Grove","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reynir T.","family":"Geirsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reynir","family":"Arngr\u00edmsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-6734-5_9"},{"key":"e_1_2_1_3_1","first-page":"596","article-title":"Prostaglandin vaginal suppositories: a simple and safe approach to the induction of labor","volume":"58","author":"Shepherd J.","year":"1981","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)90445-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347909156815"},{"key":"e_1_2_1_6_1","first-page":"137","article-title":"Prelabor evaluation of inducibility","volume":"60","author":"Lange A P.","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-6734-5_3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90311-4"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348709103649"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349009028707"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90712-X"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349109007915","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349109007915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T20:20:43Z","timestamp":1693599643000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349109007915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":10,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.3109\/00016349109007915"],"URL":"https:\/\/doi.org\/10.3109\/00016349109007915","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}