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Its effect on placental circulation was evaluated (expressed as systolic\/diastolic ratio and umbilical artery resistance index) in 20 women with severe pre\u2010eclampsia and 10 normotensive pregnant women, by using the Doppler technique. Moreover, another 10 women with severe pre\u2010eclampsia received dextrose 5% as a placebo for comparative purposes. Significant improvements in both parameters studied were observed in the women with severe pre\u2010eclampsia. The beneficial changes differed significantly from the recorded values when using dextrose in pre\u2010eclampsia or prostaglandin A, in normotensive subjects. Such promising data add another important perspective to prostaglandin A, in severe pre\u2010eclampsia and may open up new avenues for its use in other situations with compromised placental flow.<\/jats:p>","DOI":"10.3109\/00016349209007942","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:08:57Z","timestamp":1194980937000},"page":"22-27","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improving placental blood flow in pre\u2010eclampsia with prostaglandin A<sub>1<\/sub>"],"prefix":"10.1111","volume":"71","author":[{"given":"Mokhtar","family":"Toppozada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Medhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Sallam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Abdel\u2010Aziz","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u2010Sayed","family":"El\u2010Badawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah Abd","family":"Rabbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"889","volume-title":"Hypertension physiopathology and treatment2nd edn.","author":"Lindheimer M D.","year":"1983"},{"key":"e_1_2_1_3_1","first-page":"653","volume-title":"Williams Obstetrics18th edn","author":"Cunningham F G.","year":"1989"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6100.1450"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90462-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb03097.x"},{"key":"e_1_2_1_7_1","first-page":"131","article-title":"Antihypertensive effects of prostaglandin A1 in essential hypertension","volume":"21","author":"Westura E E.","year":"1970","journal-title":"Circ Res Suppl Hyperten"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)32980-5"},{"key":"e_1_2_1_9_1","first-page":"217","article-title":"Therapeutic use of PGA1 infusion in severe pre\u2010eclampsia \u2010 a major clinical potential","volume":"2","author":"Toppozada M K.","year":"1983","journal-title":"Clin Exp Hyperten"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90514-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443618909151031"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(86)90001-3"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000299092"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000299279"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06818.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90160-7"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349209007942","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349209007942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T12:59:05Z","timestamp":1698065945000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349209007942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.3109\/00016349209007942"],"URL":"https:\/\/doi.org\/10.3109\/00016349209007942","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}