{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T10:15:34Z","timestamp":1725790534907},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":6915,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>The clinical efficacy and safety of clindamycin\u2010gentamicin versus doxycycline\u2010cefoxitin in the treatment of acute pelvic inflammatory disease was evaluated in a comparative, randomized, prospective, multicenter study. Ten investigators enrolled 170 patients. Those judged to be eligible for efficacy were 60\/88 (68%) who received the clindamycin\u2010gentamicin regimen and 55\/82 (67%) of those treated with cefoxitin\u2010doxycycline. A successful clinical outcome was attained for 52\/60 (87%) and 46\/55 (84%) for patients treated with clindamycin\u2010gentamicin and cefoxitin\u2010doxycycline, respectively, a difference that was not statistically significant. In the clindamycin\u2010gentamicin series, 8\/8 (100%) of patients with positive <jats:italic>C. trachomatis<\/jats:italic> culture at baseline were culture negative at the late follow\u2010up 21\u201335 days after treatment. For those given cefoxitin\u2010doxycycline, 9\/11 (82%) who had <jats:italic>C. trachomatis<\/jats:italic> at pretreatment showed eradication at follow\u2010up. <jats:italic>Neisseria gonorrhoeae<\/jats:italic> was present at baseline in 8\/60 (13%) of the clindamycin\u2010gentamicin patients and in 9\/55 (16%) of those treated with cefoxitin\u2010doxycycline. Of those who had appropriate follow\u2010up cultures performed, 6 in the clindamycin\u2010gentamicin group and 8 in the cefoxitin\u2010doxycycline series, all showed eradication of the organism. It is concluded that clindamycin\u2010gentamicin and cefoxitin\u2010doxycycline have similar clinical cure rates for acute pelvic inflammatory disease, and based on this limited experience, it is suggested that the clindamycin\u2010gentamicin combination will satisfactorily eradicate <jats:italic>Chlamydia trachomatis<\/jats:italic> and <jats:italic>Neisseria gonorrhoeae<\/jats:italic> when either or both of these pathogens are present.<\/jats:p>","DOI":"10.3109\/00016349209007970","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:09:09Z","timestamp":1194980949000},"page":"129-134","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative evaluation of clindamycin\/gentamicin and cefoxitin\/doxycycline for treatment of pelvic inflammatory disease: A multi\u2010center trial"],"prefix":"10.1111","volume":"71","author":[{"name":"The European Study Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin L.","family":"Noah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198528020-00018"},{"key":"e_1_2_1_3_1","first-page":"113","article-title":"Criteria for diagnosis and grading of salpingitis","volume":"61","author":"Hager W D.","year":"1983","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_4_1","first-page":"122","volume-title":"Infection in the female, 2nd edn","author":"Ledger WJ","year":"1986"},{"key":"e_1_2_1_5_1","first-page":"373","article-title":"Screening for chlamydial infection in women attending family planning clinics","volume":"138","author":"Schachter J.","year":"1983","journal-title":"West J Med"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-198404000-00012"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.12.6.673"},{"issue":"10","key":"e_1_2_1_8_1","first-page":"546","article-title":"In vitro and in vivo efficacy of antimicrobials against Chlamydia trachomatis","volume":"1","author":"Bowie WR","year":"1982","journal-title":"Infection"},{"issue":"5","key":"e_1_2_1_9_1","first-page":"9","volume":"9","author":"Handsfield HD","year":"1990","journal-title":"STD Bulletin"},{"key":"e_1_2_1_10_1","first-page":"223","article-title":"Piperacillin and a combination of clindamycin and gentamicin for the treatment of hospital and community acquired acute pelvic infection including pelvic abscess","volume":"165","author":"Hemsell D L.","year":"1987","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_11_1","first-page":"282","article-title":"Comparative evaluation of clindamycin versus clindamycin plus tobramycin in the treatment of acute pelvic inflammatory disease","volume":"75","author":"Gall S A.","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_12_1","first-page":"867","article-title":"A randomized comparison of gentamicin\u2010clindamycin and cefoxitin\u2010doxycycline in the treatment of acute pelvic inflammatory disease","volume":"75","author":"Walters M D.","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03340190043029"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(69)90132-X"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349209007970","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349209007970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:32:11Z","timestamp":1698053531000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349209007970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.3109\/00016349209007970"],"URL":"https:\/\/doi.org\/10.3109\/00016349209007970","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"type":"print","value":"0001-6349"},{"type":"electronic","value":"1600-0412"}],"subject":[],"published":{"date-parts":[[1992,2]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}