{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:59:01Z","timestamp":1761058741368},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":6368,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:p><jats:italic>Aim of study<\/jats:italic>. We investigated to which degree IgG, IgA and IgM anti\u2010cardiolipin antibodies (aCL) are associated in recurrent abortion or late fetal death with other signs of autoimmune disease and in particular SLE.<\/jats:p><jats:p><jats:italic>Material and methods<\/jats:italic>. Serological variables typical of SLE and of the anti\u2010phospholipid antibody syndrome were measured once eight to 16 weeks after the last fetal loss in 158 women with recurrent abortion or late fetal death; women with manifest autoimmune rheumatic disease were excluded.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. (1) Positive values, i.e. above the 99th percentile of reference material, of IgG aCL and IgA aCL were observed in 4% and 7%, respectively, whereas 26% had positive values of IgM aCL. (2) IgG aCL and IgA aCL but not IgM aCL correlated to anti\u2010nuclear antibodies and to anti\u2010double stranded DNA. (3) Anti\u2010double stranded DNA, IgG aCL and IgA aCL but not IgM aCL correlated to previous occurrence of thrombosis. (4) ANA correlated to lower blood platelet concentrations and higher erythrocyte sedimentation rates<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>. Women with recurrent abortion or late fetal death who have higher but not necessarily abnormally high levels of IgG aCL or IgA aCL constitute a group with increased occurrence of clinical and serological characteristics of SLE. We suggest that these women be kept under surveillance for future development of autoimmune disease especially SLE. The women with high IgM aCL constitute another group without these characteristics.<\/jats:p>","DOI":"10.3109\/00016349309021136","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:46:13Z","timestamp":1195692373000},"page":"465-469","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti\u2010cardiolipin antibodies (IgG and IgA) in women with recurrent fetal loss correlate to clinical and serological characteristics of SLE"],"prefix":"10.1111","volume":"72","author":[{"given":"Peter Valdemar","family":"Bagger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vagn","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Baslund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjarne","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanne","family":"Hove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi","family":"H\u00f8ier\u2010Madsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Philip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Schaadt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven Olav","family":"Skouby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Starup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sixtus","family":"Thorsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Wiik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90335-2"},{"key":"e_1_2_1_3_1","first-page":"155","article-title":"Affinity purified anti\u2010cardiolipin and anti\u2010DNA antibodies","volume":"17","author":"Harris EN","year":"1985","journal-title":"J Clin Lab Immunol"},{"key":"e_1_2_1_4_1","first-page":"1","article-title":"Crossreactivity of antiphospholipid antibodies","volume":"16","author":"Harris EN","year":"1985","journal-title":"J Clin Lab Immunol"},{"key":"e_1_2_1_5_1","first-page":"178","article-title":"The specificity of anti\u2010cardiolipin antibodies from syphilis patients and from patients with systemic lupus erythematosus","volume":"76","author":"Mouritsen S.","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb00242.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0002-9343(88)80228-6","article-title":"Solid\u2010phase anti\u2010cardiolipin test revisited","volume":"85","author":"Harris EN","year":"1988","journal-title":"Am J Med"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91267-9"},{"key":"e_1_2_1_9_1","first-page":"263","article-title":"Lupus anticoagulants","volume":"6","author":"Shapiro SS","year":"1982","journal-title":"Prog Hemostasis Thromb"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60777-4"},{"key":"e_1_2_1_11_1","first-page":"3","article-title":"Pregnancy and aPL","volume":"40","author":"Sammaritano LA","year":"1991","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.5.358"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/98.4.449"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91619-6"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830260208"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.5.362"},{"key":"e_1_2_1_17_1","first-page":"1849","article-title":"Clinical utility and specificity of anticardiolipin antibodies","volume":"18","author":"Soloninka CA","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90218-3"},{"key":"e_1_2_1_19_1","first-page":"482","article-title":"Primary antiphospholipid syndrome","volume":"16","author":"Alarcon\u2010Segovia D.","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198911000-00004"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/26.5.324"},{"key":"e_1_2_1_22_1","first-page":"486","article-title":"The anticardiolipin syndrome","volume":"13","author":"Hughes G RV","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.5.355"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1182\/blood.V66.5.1086.1086","article-title":"\u03b22\u2010glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway","volume":"66","author":"Schousboe I.","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339200100204"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1987.tb02207.x"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","unstructured":"HumbelR. KaduschP.(1985)Use of HEp\u20102 cells in the IF test for detection of antinuclear antibodies. Protides of the biological fluids. Proceedings of the thirty\u2010third colloquium.1985 H.Peeters.Pergamon Press Oxford 385\u20137.","DOI":"10.1016\/B978-0-08-033215-4.50095-9"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300601"},{"key":"e_1_2_1_30_1","first-page":"289","article-title":"False positive ELISA tests for anticardiolipin antibodies in sera from patients with repeated abortions rheumatologic disorders and primary biliary cirrhosis: correlation with elevated polyclonal IgM and implications for patients with repeated abortion","volume":"73","author":"Cowchock S.","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/oxfordjournals.humrep.a136408","article-title":"Autoimmunity, fetal losses, lupus anticoagulant: beginning of systemic lupus erythematosus or new autoimmune entity with gynaec\u2010o\u2010obstetrical expression","volume":"1","author":"Edelman P.","year":"1986","journal-title":"Human Reprod"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.3.353"},{"key":"e_1_2_1_33_1","first-page":"269","article-title":"Evaluation of the cross\u2010reaction between anti\u2010DNA and anticardiolipin antibodies in SLE and experimental animals","volume":"65","author":"Eilat D.","year":"1986","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_34_1","first-page":"298","article-title":"Antibodies cross\u2010reactive with DNA and cardiolipin in patients with systemic lupus erythematosus","volume":"50","author":"Koike T.","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198302243080802"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(90)90021-Z"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.11.805"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.4.245"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)80140-4"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349309021136","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349309021136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T23:27:57Z","timestamp":1698276477000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349309021136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.3109\/00016349309021136"],"URL":"https:\/\/doi.org\/10.3109\/00016349309021136","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,8]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}