{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:35:00Z","timestamp":1780083300200,"version":"3.54.0"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":6460,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) vaginal tablets, suppositories and gel are increasingly being used for the induction of labor. Ease of administration and supervision are their greatest advantage, while hyperstimulation and rupture of the uterus are the main risks. <jats:italic>Case<\/jats:italic>. A 26\u2010year\u2010old woman, gravida 5, para 2, with no history of cesarean section, was induced at 40 weeks' normal gestation, because of mild pregnancy\u2010induced hypertension. Haif a tablet (1.5 mg) of PGE<jats:sub>2<\/jats:sub> was inserted into the cervix. Three hours later, tetanic uterine contractions started. In a precipitated labor she delivered a female weighing 3,250 gr, about 20 minutes after the appearance of uterine contractions. Severe post partum hemorrhage occurred, and examination disclosed an isthmical uterine rupture. Subtotal hysterectomy was performed at laparotomy. The postoperative course was uneventful.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. The use of PGE<jats:sub>2<\/jats:sub> should be of concern in multiparous patients, or those with scarred uteri. This case highlights the risk of even a small dose of PGE<jats:sub>2<\/jats:sub> administered into the cervix.<\/jats:p>","DOI":"10.3109\/00016349309068046","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:45:57Z","timestamp":1195692357000},"page":"316-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Uterine rupture with the use of a low\u2010dose vaginal PGE<sub>2<\/sub> tablet"],"prefix":"10.1111","volume":"72","author":[{"given":"Foad","family":"Azem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Jaffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Lessing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Reuben","family":"Peyser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90278-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6182.108"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1979.tb10680.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91234-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0002-9378(16)33046-0","article-title":"Uterine rupture with the use of vaginal prostaglandin E2 suppositories","volume":"134","author":"Sandier R Z.","year":"1979","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_7_1","first-page":"615","article-title":"Uterine hyperstimulation and rupture after induction of labour with prostaglandin E2","volume":"65","author":"Larsen J V.","year":"1984","journal-title":"S Afr Med J"},{"key":"e_1_2_1_8_1","first-page":"459","article-title":"Cervical ripening with intravaginal prostaglandin E2 gel","volume":"61","author":"Prins R P.","year":"1983","journal-title":"Obstet Gynecol"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349309068046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349309068046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T08:54:40Z","timestamp":1698224080000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349309068046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.3109\/00016349309068046"],"URL":"https:\/\/doi.org\/10.3109\/00016349309068046","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}