{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:22:11Z","timestamp":1760188931015},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":6003,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. To study the influence of pre\u2010conceptional health status and immunosuppressive drug regimen on pregnancy outcome in renal allograft recipients.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. The study includes all pregnancies in renal allograft recipients in Norway in the period 1973\u20101991. The data were collected from the patient records. Serum\u2010creatinine values, proteinuria. blood pressure, recent graft rejection, and immunosuppressive drug regimen before pregnancy as well as the interval from transplantation until pregnancy were related to the frequency of deliveries at term, preterm deliveries, and of induced and spontaneous abortions<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. 54 pregnancies in 37 renal allograft recipients resulted in 31 term deliveries, 12 preterm deliveries, four spontaneous, and seven induced abortions. One induced abortion due to psychosocial reasons was excluded from the calculations. Post\u2010transplant intervals less than two years as compared to longer intervals were associated with an increased frequency of spontaneous and induced abortions (6\/13 vs 4\/40. <jats:italic>p<\/jats:italic> &lt; 0.01) and a non\u2010significant increase in the relation between preterm and term deliveries (3\/4 vs 9\/27). The few women with proteinuria, elevated serum\u2010creatinine values, and hypertension before pregnancy had an increased number of adverse pregnancy results. The women receiving cyclosporine A experienced a larger frequency of spontaneous and induced abortions (7\/18 vs 3\/35, <jats:italic>p<\/jats:italic>&lt; 0.05) and an increase in the relation between preterm and term deliveries (714 vs 5\/27, <jats:italic>p<\/jats:italic>&lt;0.01) as compared to the women who received prednisolone and azathioprine only.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>. The results demonstrate the importance of pre\u2010conceptional consultation and may indicate a harmful effect of cyclosporine A on pregnancy outcome.<\/jats:p>","DOI":"10.3109\/00016349409006270","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:11:03Z","timestamp":1194981063000},"page":"541-546","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Pregnancy outcome in renal allograft recipients in Nor"],"prefix":"10.1111","volume":"73","author":[{"given":"Guttorm","family":"Haugen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Fauchald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"S\u00f8dal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f8rn","family":"Leivestad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narve","family":"Moe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)81116-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1976.tb00879.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1973.tb08137.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15205.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1985.tb04044.x"},{"key":"e_1_2_1_7_1","first-page":"573","article-title":"Perinatal outcome in renal allo\u2010graft recipients: Prognostic significance of hypertension and renal function before and during pregnancy","volume":"78","author":"Sturgiss S. N.","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_8_1","first-page":"327","article-title":"Nyretransplantasjon i Norge","volume":"110","author":"Albrechtsen D.","year":"1990","journal-title":"Tidsskr Nor L\u00e6geforen"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01088.x"},{"key":"e_1_2_1_10_1","first-page":"4414","article-title":"Chromosome aberrations in the child of a kidney transplant recipient","volume":"128","author":"Leb D. 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