{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:53:48Z","timestamp":1784584428737,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":6215,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p><jats:italic>Introduction:<\/jats:italic> The objective of this study was to determine whether the circulatory levels of endothelins, potent vasoconstrictor polypeptides produced mainly by endothelial cells, are increased in growth\u2010retarded fetuses.<\/jats:p><jats:p><jats:italic>Study design:<\/jats:italic> Fetal venous serum samples, withdrawn by ultrasound\u2010guided cordocentesis from 11 growth\u2010retarded fetuses and 10 normally\u2010growing fetuses who underwent the procedure because of other unrelated indications, were examined for immunoreactive endothelin\u20101,2 by radioimmunoassay.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Higher mean endothelin\u20101,2 levels were found in the sera of growth\u2010retarded fetuses than in controls (16.8 \u00b1 4.2 versus 10.9 \u00b1 4.3 fmol\/ml, <jats:italic>p<\/jats:italic> = 0.008). Within the growth\u2010retarded group, there were no differences in endothelin\u20101,2 levels in the presence of either abnormal umbilical Doppler, asymmetry of growth\u2010retardation, maternal signs of preeclampsia, or fetal acidosis.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> High levels of endothelin\u20101,2 in the fetoplacental circulation may be pathophysiological important in fetal growth retardation. However, the clinical significance of these elevated levels is yet to be determined.<\/jats:p>","DOI":"10.3109\/00016349409013387","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:10:16Z","timestamp":1194981016000},"page":"21-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Endothelin\u20101,2 levels in umbilical vein serum of intra\u2010uterine growth retarded fetuses as detected by cordocentesis"],"prefix":"10.1111","volume":"73","author":[{"given":"Eyal","family":"Schiff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Zalel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Mashiach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha M.","family":"Sibai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer","family":"Shalev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"e_1_2_1_3_1","first-page":"205","article-title":"Increased plasma endothelin level in patients with essential hypertension","volume":"332","author":"Saito Y.","year":"1990","journal-title":"N Engl J Med (letter)"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-6-464"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(05)80315-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910193211614"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-6-1675"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011223232113"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91688-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90317-K"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91688-Q"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199100177-00088"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb14409.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92523-0"},{"key":"e_1_2_1_15_1","first-page":"122","article-title":"Preeclampsia: A review of the role of prostaglandins","volume":"71","author":"Friedman S. 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