{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:29:59Z","timestamp":1780050599865,"version":"3.53.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T00:00:00Z","timestamp":1294963200000},"content-version":"vor","delay-in-days":5949,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Pre\u2010eclampsia is regarded as a primary placental disorder, in which defect placentation causes endothelial and cardiovascular disturbances. Evidence of disturbed neural cardiovascular control in this condition has been suggested, as well as in other hypertensive diseases. The purpose of the present study was to non\u2010invasively evaluate the sympatho\u2010vagal balance during normal and pre\u2010eclamptic pregnancy.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. In twelve healthy pregnant women, thirteen pre\u2010eclaniptic women and ten non\u2010pregnant controls. Heart rate, blood pressure and breathing movements were registered and recorded on B tape recorder for off\u2010line analysis. Variability in heart rate, blood pressure and breathing movements were computed by an autoregressive spectral analysis algorithm. Heart rate variability was quantitated as the area under the spectral curve, and Student's t\u2010test was performed on logarithmic values.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Heart rate variability contained two major components in power, a low frequency peak predominantly attributed to sympathetic tone, and a high frequency peak reflecting vagal tone. Women with pre\u2010eclampsia were characterized by a significantly reduced high frequency peak compared to healthy pregnant (<jats:italic>p<\/jats:italic> = 0.03) and non\u2010pregnant (<jats:italic>p<\/jats:italic> = 0.02) women. In the low frequency band there were no significant differences in power between the groups. Blood pressure variability did not differ between the groups.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. The present results indicate that pre\u2010eclampsia is associated with decreased vagal control of the heart. Furthermore, the results indicate that pregnancy <jats:italic>per se<\/jats:italic> does not change sympatho\u2010vagal balance.<\/jats:p>","DOI":"10.3109\/00016349409029402","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:46:47Z","timestamp":1195692407000},"page":"680-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Autonomic cardiovascular control in normal and pre\u2010eclamptic pregnancy"],"prefix":"10.1111","volume":"73","author":[{"given":"Eva","family":"Eneroth\u2010Grimfors","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Westgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Ericson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ihrman\u2010Sandahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Erik","family":"Lindblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348809029863"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1982.tb04661.x"},{"key":"e_1_2_1_4_1","first-page":"594","article-title":"Plasma noradrenaline and adrenaline in pre\u2010eclampsia, essential hypertension in pregnancy and normotensive pregnant control subjects","volume":"99","author":"Pedersen EB","year":"1982","journal-title":"Acta Endocrinol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348609158398"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(85)90040-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1992.tb00356.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6166045"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198809000-00004"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1991.tb01391.x"},{"key":"e_1_2_1_11_1","article-title":"Effects of till and treadmill exercise on short\u2010term variability in systolic arterial pressure in hypertensive men","volume":"5","author":"Furlan R.","year":"1987","journal-title":"J Hypertens"},{"key":"e_1_2_1_12_1","first-page":"10","article-title":"Microcomputer based system for R\u2010R interval detection and autoregressive spectral analysis of variability in biological signals","author":"Ericson MO","year":"1991","journal-title":"Technical report"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90445-Q"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4809(89)90036-0"},{"key":"e_1_2_1_15_1","article-title":"Assessment of autonomic function in humans by heart rate spectral analysis","volume":"248","author":"Pomeranz B.","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_1_16_1","first-page":"43","article-title":"Sympathovagal interaction during mental stress. 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