{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T04:28:48Z","timestamp":1768192128703,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":5911,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The amount of free \u03b2 subunit hCG (free \u03b2) has been reported to be increased in trophoblast disease and Down's syndrome, conditions also associated with high total hCG. Increased total hCG has been reported in hyperemesis gravidarum. We sought to determine if sera from singleton gestations with hyperemesis gravidarum contained a higher proportion of free \u03b2 hCG compared to controls of comparable gestational age.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Sera from 39 patients with hyperemesis gravidarum was compared with that from 23 control subjects of comparable gestational age with respect to \u03b2 hCG and its subunits (free \u03b2 and free \u03b1).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Hyperemesis patients and controls were comparable with respect to age, weight and gestational age. The concentration of hCG was greater in hyperemesis patients (9237 \u00b1 3613 ng\/ml, mean \u00b1 s.d.) compared to controls (5543 \u00b1 2290, <jats:italic>p<\/jats:italic> &lt; 0.005) as was the concentration of free \u03b2 hCG (101\u00b170 ng\/ml vs. 31 + 31,<jats:italic>p<\/jats:italic> &lt; 0.001). Free \u03b1 did not differ between hyperemesis patients and controls (399\u00b1231 ng\/ml vs. 377\u00b1214). A percent free \u03b2 greater than 0.6 was found in 33\/39 hyperemesis patients (85%) compared to 5\/23 controls (22%),<jats:italic>p<\/jats:italic> &lt; 0.001. <jats:italic>Conclusion<\/jats:italic>. Increased free \u03b2 hCG is found in hyperemesis gravidarum. This finding, strengthens the association of hyperemesis with abnormal metabolism of hCG.<\/jats:p>","DOI":"10.3109\/00016349409072502","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:46:56Z","timestamp":1195692416000},"page":"770-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Increased concentration of the free \u03b2\u2010subunit of human chorionic gonadotropin in hyperemesis gravidarum"],"prefix":"10.1111","volume":"73","author":[{"given":"Thomas Murphy","family":"Goodwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome M.","family":"Hershman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.3.704"},{"key":"e_1_2_1_3_1","first-page":"72","article-title":"A prospective evaluation of a second\u2010trimester screening test for fetal Down sundrome using maternal serum alpha\u2010fetoprotein, hCG, and unconjugated estriol","volume":"81","author":"Cheng E. Y.","year":"1993","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90809-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90700-H"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1200155"},{"key":"e_1_2_1_7_1","first-page":"696","article-title":"Nausea and vomiting of pregnancy: role of human chorionic gonadotropin and 17\u2010hyd\u2010roxyprogesterone","volume":"55","author":"Soules M. R.","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90126-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.5.1333"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6179.1670"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/clinchem\/38.1.26","article-title":"Polypeptide nicks cause erroneous results in assays of human chorionic gonadotropin free\u2010\u03b2 subunit","volume":"38","author":"Kardana A.","year":"1992","journal-title":"Clin Chem"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(68)90445-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-3-1551"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349409072502","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349409072502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:16:42Z","timestamp":1698110202000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349409072502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1994,11]]}},"alternative-id":["10.3109\/00016349409072502"],"URL":"https:\/\/doi.org\/10.3109\/00016349409072502","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}