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Cadmium alone inhibited spontaneous contractile activity already in a concentration of 10<jats:sup>\u22129<\/jats:sup> M and in 10<jats:sup>\u22123<\/jats:sup> M myometrial contractions were almost completely abolished. Responses to Ca<jats:sup>2+<\/jats:sup> and oxytocin were significantly increased by exposure to cadmium in low concentration (10<jats:sup>\u22129<\/jats:sup> M\u201010<jats:sup>\u22128<\/jats:sup> M), whereas higher concentration of Cd<jats:sup>2+<\/jats:sup> had inhibitory action. These results suggest that cadmium not only blocks Ca<jats:sup>2+<\/jats:sup> channels in the human my\u2010ometrium. but also interferes with intracellular mechanisms involved in excitation\u2010contraction coupling. The increased responses to Ca<jats:sup>2+<\/jats:sup> and oxytocin in the presence of low amounts of Cd<jats:sup>2+<\/jats:sup> support a role of cadmium in mechanisms of preterm labor.<\/jats:p>","DOI":"10.3109\/00016349509008914","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T19:11:16Z","timestamp":1194981076000},"page":"93-96","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of cadmium on myometrial activity of the nonpregnant human. 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