{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:18:02Z","timestamp":1789690682107,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,1,17]],"date-time":"2011-01-17T00:00:00Z","timestamp":1295222400000},"content-version":"vor","delay-in-days":5587,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. To reevaluate whether spironolactone, a steroid receptor antagonist, is effective in improving premenstrual syndrome (PMS) in a double\u2010blind, placebo\u2010controlled cross over study.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Thirty\u2010five women with PMS were given one tablet of 100 mg spironolactone or placebo daily from day 14 of the menstrual cycle until the first day of the following menstruation. Two pretreatment cycles were observed for diagnosis in each woman, followed by 6 treatment cycles with spironolactone and placebo applied in either the first or second 3 months. The assessment of symptoms and diagnosis of PMS were based on prospective daily self\u2010ratings made by the women using a validated visual analogue scale.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. The treatment with spironolactone was associated with an improvement in PMS symptoms compared to placebo as judged by significant decrease in negative mood symptom scores (<jats:italic>p<\/jats:italic> &lt; 0.001) and somatic symptom scores (<jats:italic>p<\/jats:italic> &lt; 0.001). Of the individual symptoms, spironolactone significantly improved irritability, depression, feeling of swelling, breast tenderness and food craving in comparison to placebo. A lasting effect of spironolactone was observed in women started with spironolactone after cross over to placebo.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>. Spironolactone appears to be an effective therapy for the negative mood changes and somatic symptoms in PMS.<\/jats:p>","DOI":"10.3109\/00016349509021201","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:47:55Z","timestamp":1195692475000},"page":"803-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Treatment of premenstrual syndrome by spironolactone: A double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"74","author":[{"given":"Mingde","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hammarb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt\u2010\u00c5ke","family":"Lindhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f6rn","family":"B\u00e4ckstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199209000-00021"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348509155154"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.6.1347506"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6281892"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196909000-00015"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(69)90075-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1979.tb10582.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(91)90357-B"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1991.tb02824.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-198312000-00003"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/01674828909016676"},{"key":"e_1_2_1_13_1","volume-title":"American Psychiatric Association, eds. Diagnostic and statistical manual of mental disorders (DSM\u2010III\u2010R). 3rd edn (revised)","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348809004191"},{"key":"e_1_2_1_15_1","first-page":"17","article-title":"Spironolactone for premenstrual syndrome","volume":"5","author":"Hendler NH","year":"1980","journal-title":"Female Patient"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007998709112403"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6917.1471"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349309068030"},{"key":"e_1_2_1_19_1","first-page":"429","article-title":"Effect of spironolactone on premenstrual syndrome","volume":"32","author":"Vellacott ID","year":"1987","journal-title":"J Reprod Med"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349309021108"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349509021201","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349509021201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T21:46:02Z","timestamp":1698356762000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349509021201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.3109\/00016349509021201"],"URL":"https:\/\/doi.org\/10.3109\/00016349509021201","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]},"assertion":[{"value":"2011-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}