{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:59:23Z","timestamp":1789660763120,"version":"4.0.1"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":5454,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> To further investigate the relationship between inappropriate gonadotropin. hyperinsulinemia and androgen excess.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> We divided women with polycystic ovarian syndrome (PCOS) into two groups on the basis of LH\/FSH (LH\/FSH \u22653, Group 1. <jats:italic>n<\/jats:italic>=30: LH\/FSH&lt;3, Group 2, <jats:italic>n<\/jats:italic>=25) and measured the responses of insulin. C\u2010peptide (C\u2010P). C\u2010P\/insulin (C\u20101) and testosterone concentrations to an oral glucose tolerance test (OGTT) in these patients and 15 control subjects. Results. Significant positive correlations were found between basal LH and T (<jats:italic>r<\/jats:italic>\u20100.58. <jats:italic>p<\/jats:italic>&lt;0.05) in Group 1, and between fasting serum insulin and T (<jats:italic>r<\/jats:italic>=0.48. <jats:italic>p<\/jats:italic>&lt;0.05) in Group 2. Although these patients had higher, delayed insulin and C\u2010P responses to OGTT than the control group, much greater insulin and C\u2010P levels and lower C\/I values were found in Group 2. T concentrations decreased mildly during OGTT in Group 1 and the control, while they increased slightly in Group 2.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Our data suggest that hyperinsulinemia in PCOS is due to a enhanced \u03b2\u2010cell secretion and an impaired hepatic clearance of this hormone, hyperandrogenism may be LH\u2010dependent in Group 1 and insulin\u2010dependent in Group 2.<\/jats:p>","DOI":"10.3109\/00016349609033311","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:48:11Z","timestamp":1195692491000},"page":"166-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Different responses of insulin, C\u2010peptide, and testosterone to an oral glucose tolerance test in two groups of women with polycystic ovarian syndrome"],"prefix":"10.1111","volume":"75","author":[{"given":"Wu Xiao","family":"Ke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu Qiu","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Yan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"143","article-title":"The role of insulin in the pathogenesis of polycystic ovarian syndrome","volume":"2","author":"Wu X. K.","year":"1993","journal-title":"J Reprod Med"},{"key":"e_1_2_1_3_1","first-page":"80","article-title":"Types of hyperinsulinemia in polycystic ovarian syndrome","volume":"3","author":"Wu X. K.","year":"1994","journal-title":"J Reprod Med"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54352-0"},{"key":"e_1_2_1_5_1","first-page":"388","article-title":"Clinical findings and hormonal responses in patients with polycystic ovarian disease with normal versus elevated LH level","volume":"47","author":"Givens J. R.","year":"1986","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55249-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0015-0282(16)59293-0","article-title":"Androgen and insulin response to an oral glucose challenge in hyperandrogenic women","volume":"48","author":"Smith S.","year":"1988","journal-title":"Fertil Steril"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.2.305"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112758"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349609033311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349609033311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T09:59:44Z","timestamp":1698400784000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349609033311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.3109\/00016349609033311"],"URL":"https:\/\/doi.org\/10.3109\/00016349609033311","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}