{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:44:41Z","timestamp":1761155081601},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":5394,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p><jats:bold><jats:italic>Background.<\/jats:italic><\/jats:bold> Treatment of menorrhagia by heat\u2010destruction of the endometrium, intended to be an alternative to hysterectomy, was investigated in an experimental study. Method. A specially designed catheter (Cavaterm<jats:sup>tm<\/jats:sup>) with a silicone balloon containing a self\u2010regulating heating element is inserted into the uterus, filled with glycine to a pressure of around 180 mmHg and heated to about 75\u00b0C. We investigated the treatment effect <jats:italic>in vitro<\/jats:italic> in five extirpated uteri (series A) and <jats:italic>in vivo<\/jats:italic> in three patients treated peroperatively just before hysterectomy, temperatures being monitored in the surrounding tissues (series B). In both series we monitored the following variables: heating\u2010power, balloon\u2010pressure, temperature of the heating element (around 85d`gC) and the temperatures at five locations from top to bottom of the balloon surface.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> After 30 min <jats:italic>in vitro<\/jats:italic> treatment at 75\u00b0C, the endometrium was partly destructed, and condensed. Histological examination showed smooth muscle cells to be destroyed to a depth of 2\u20105 mm close to the endometrium.<\/jats:p><jats:p>With <jats:italic>in vivo<\/jats:italic> treatment for 30 min at a heating power of about 20 W (resulting in balloon surface temperatures of 58\u201065\u00b0C). the increases in temperature of the surrounding tissue were too small to measure accurately (\u00b11\u00b0C). Histological examination showed destruction of cells in the corpus uteri to a maximum depth of 8 mm.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Findings in <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> experiments suggest that 30 min heating of the endometrium to 58\u201065\u00b0C with an intrauterine silicone balloon filled with a liquid to a pressure of 180 mmHg exerts therapeutic effects on both endometrium and uterine cavity smooth muscle cells without damage to surrounding tissues.<\/jats:p>","DOI":"10.3109\/00016349609033325","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:48:30Z","timestamp":1195692510000},"page":"330-335","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Endometrial Destruction by Hyperthermia \u2014 a Possible Treatment of Menorrhagia"],"prefix":"10.1111","volume":"75","author":[{"given":"Brut","family":"Friberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertil R. R.","family":"Persson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Will\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Ahlgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb16240.x"},{"key":"e_1_2_1_3_1","first-page":"248","article-title":"Konsensusuttalande. Ta bort livmodern? Orsaker, metoder och alternativ","author":"SPRI","year":"1993","journal-title":"Spri tryck"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90466-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90251-9"},{"key":"e_1_2_1_6_1","first-page":"93","article-title":"Surgical alternatives to hysterectomy for intractable menorrhagia","volume":"44","author":"Boto T C A.","year":"1990","journal-title":"Br J Hosp Med"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90207-L"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199011000-00032"},{"key":"e_1_2_1_9_1","unstructured":"BroadbentJ A M. MolnarB. G. RichardsonR. E. BournasN. MagosA. L..Life table analysis of treatment failure in the first four years after endometrial resection.Abstract Book 2nd European Congress in Gynaecological Endoscopy and New Surgical Techniques Heidelberg Germany Oct 2123 1993 13\u20134."},{"key":"e_1_2_1_10_1","unstructured":"SingerA. TiernanC. M. MacDonaldR..Five years experience of total endometrial ablation.Abstract Book 2nd European Congress in Gynaecological Endoscopy and New Surgical Techniques Heidelberg Germany Oct 2123 1993;119."},{"key":"e_1_2_1_11_1","first-page":"792","article-title":"The endometrial ablator: A new instrument","volume":"83","author":"Neuwirth R. S.","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_12_1","first-page":"732","article-title":"Preliminary clinical experience with a thermal balloon endometrial ablation method to treat menorrhagia","volume":"83","author":"Singer A.","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_13_1","volume-title":"A new, simple, safe and efficient device for the treatment of menorrhagia","author":"Friberg B."},{"key":"e_1_2_1_14_1","unstructured":"LindholmC\u2010E.Hyperthermia and Radiotherapy. A study on malignant superficial tumours.Doctorial theses Lund1992."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)91443-Z"},{"key":"e_1_2_1_16_1","first-page":"691","article-title":"Mechanical preparation of the endometrium prior to endometrial ablation","volume":"37","author":"Gimpelson R. J.","year":"1992","journal-title":"J Reprod Med"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1976.tb00911.x"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349609033325","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349609033325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:24:17Z","timestamp":1698362657000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349609033325"}},"subtitle":["An experimental study"],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.3109\/00016349609033325"],"URL":"https:\/\/doi.org\/10.3109\/00016349609033325","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}