{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:48:29Z","timestamp":1760906909746},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":5394,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p><jats:bold><jats:italic>Objectives.<\/jats:italic><\/jats:bold> To evaluate the incidence of toxic hepatitis associated with the use of ritodrine in pregnancy.<\/jats:p><jats:p><jats:italic>Design.<\/jats:italic> A prospective study.<\/jats:p><jats:p><jats:italic>Setting.<\/jats:italic> A large teaching hospital in Barcelona. Spain.<\/jats:p><jats:p>Patients: One hundred and twenty\u2010three consecutive pregnant women, 101 singleton and 22 multiple pregnancies, receiving intravenous ritodrine with normal transaminase levels prior to the initiation of therapy.<\/jats:p><jats:p><jats:italic>Measurements.<\/jats:italic> Serum glutamic pyruvic transaminase (SGPT) and glutamic oxaloacetic transaminase (SGOT). gamma\u2010glutamyl transpeptidase (GGT). alkaline phosphatase (PA), direct and total bilirubin.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> In two (1.9%) of 101 singleton and two (9.1%) of 22 multiple pregnancies, elevation of SGOT and SGPT levels was detected. PA, GGT, and bilirubin were normal in all women studied. Other causes of hepatitis were ruled out, and no other signs of liver impairment were found in these women. Transaminase levels recovered rapidly in all cases after discontinuation of therapv<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Elevation of liver enzymes is a rare complication of ritodrine. Discontinuation of therapy does not appear to be indicated as long as other signs of liver dysfunction are not present and tocolytic treatment is required.<\/jats:p>","DOI":"10.3109\/00016349609033327","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:48:33Z","timestamp":1195692513000},"page":"340-342","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Toxic Hepatitis: a Rare Complication Associated with the use of Ritodrine During Pregnancy"],"prefix":"10.1111","volume":"75","author":[{"given":"Francisco","family":"de Arcos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Gratac\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Palacio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicen\u00e7","family":"Cararach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0002-9378(82)90366-0","article-title":"Severe hemolytic anemia, leukemoid reaction, acidosis, hypokaliemia, and transient hepatitis associated with the administration of ritodrine hydrochloride (Yu\u2010topar)","volume":"144","author":"Alcena V.","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_3_1","first-page":"14S","article-title":"Maternal liver impairment associated with prolonged high\u2010dose administration of terbutaline for premature labor","volume":"66","author":"Suzuki M.","year":"1985","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90837-9"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(94)90029-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347709155014"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)33300-7"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349609033327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349609033327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:24:24Z","timestamp":1698362664000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349609033327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.3109\/00016349609033327"],"URL":"https:\/\/doi.org\/10.3109\/00016349609033327","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}