{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:01:11Z","timestamp":1773424871528,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":5364,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:p>Objective, To compare the effect of endothelin on isolated resistance arteries from different vascular beds in normal and preeclamptic women before and after pretreatment with the ETA receptor antagonist BQ\u2010123.<\/jats:p><jats:p>Materials and methods. Resistance arteries from myometrial and omental biopsies obtained at cesarean section of normal pregnant and preeclamptic women were dissected and mounted in organ baths for recording of isometric tension. The contractile response to endothelin\u20101 in presence and absence of BQ\u2010123 was recorded.<\/jats:p><jats:p>Results. Endothelin\u20101 induced similar concentration\u2010dependent contractions in all arteries investigated. In women with preeclampsia the contractile response induced by endothelin\u20101 was significantly higher in omental as compared to myometrial vessels. Pretreatment with BQ\u2010123 significantly shifted the concentration\u2010response curve to the right but only reduced the maximum contractile response in omental vessels.<\/jats:p><jats:p>Conclusion. Endothelin\u20101 is a potent constrictor of resistance arteries from different vascular beds in normal pregnancy and preeclampsia. The contractile effect is at least in part mediated by ETA receptors, since it was significantly reduced after pretreatment with BQ\u2010123. In preeclamptic but not in normal pregnant women the response to endothelin\u20101 was reduced in myometrial as compared to omental arteries, possibly secondary to receptor down regulation.<\/jats:p>","DOI":"10.3109\/00016349609033349","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:48:42Z","timestamp":1195692522000},"page":"432-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of endothelin\u20101 and the ET<sub>A<\/sub> receptor antagonist BQ\u2010123 on resistance arteries from normal pregnant and preeclamptic women"],"prefix":"10.1111","volume":"75","author":[{"given":"Kerstin","family":"Wolff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina\u2010Rasa","family":"Kublickiene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Kublickas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lindblom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils\u2010Olov","family":"Lunell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Nisell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2863"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/348730a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/348732a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/348673a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.3.1203"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000138941"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90389-Z"},{"key":"e_1_2_1_9_1","first-page":"1486","article-title":"(1990;) Plasma endothelin\u20101 levels in patients with pregnancy\u2010induced hypertension","volume":"22","author":"Kamoi K.","year":"1990","journal-title":"N Engl J Med"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-6-1675"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91688-7"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199112006-00068"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000292619"},{"key":"e_1_2_1_14_1","volume-title":"Biological profiles of highly potent novel endothelin antagonists selective for the ET","author":"Ihara M."},{"key":"e_1_2_1_15_1","volume-title":"Evidence for endothelin induced renal vasoconstriction independent of ET","author":"Pollock D. 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