{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:13:05Z","timestamp":1760044385898},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":5333,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic> Congenital nephrotic syndrome of the Finnish type [CNF] is an autosomal recessive disorder leading to death in early childhood, if treated conservatively without early renal transplantation. Prenatal screening at midtrimester is feasible by measuring maternal serum alpha\u2010fetoprotein [MSAFP], elevated amniotic fluid [AF] AFP being the only diagnostic test in population screening. We studied whether concentrations of other pregnancy\u2010related markers offer any ancillary procedure for screening.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> In a prospective case\u2010control study, the concentrations of maternal serum human chorionic gonadotropin [hCG], unconjugated estriol [uE<jats:sub>3<\/jats:sub>], human placental lactogen [hPL] and placental protein 14 [pp14] were measured in samples from six singleton pregnancies associated with fetal CNF and from 18 matched controls at 15 weeks of gestation.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> In the CNF group, mean hCG and pp 14 concentrations were slightly elevated, whereas uE<jats:sub>3<\/jats:sub> and hPL concentrations were within the lower normal range. None of these differences were statistically significant and the distribution of these values was too wide to use them for screening.<\/jats:p><jats:p><jats:italic>Conclusions.<\/jats:italic> Low unconjugated E<jats:sub>3<\/jats:sub> and elevated hCG concentrations were expected, since newborns with CNF are growth\u2010retarded and have large placentas. The extent of these alterations was not sufficient to identify high risk pregnancies. Substantial differences in the maternal serum concentrations of hPL and pp 14 were not observed. Hence, MSAFP screening at midtrimester is the strategy of choice for prenatal detection of CNF.<\/jats:p>","DOI":"10.3109\/00016349609054665","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:48:46Z","timestamp":1195692526000},"page":"526-530","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endometrial and fetoplacental markers in pregnancies with fetal congenital nephrosis"],"prefix":"10.1111","volume":"75","author":[{"given":"Seppo","family":"Heinonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"Ryyn\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pertti","family":"Kirkinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Saarikoski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Antenatal screening for congenital nephrosis in Finland by maternal serum alpha\u2010fetoprotein","author":"Ryyn\u00e4nen M.","year":"1981"},{"key":"e_1_2_1_3_1","first-page":"984","article-title":"Prenatal diagnosis of congenital nephrosis in 23 high\u2010risk families","volume":"132","author":"Aula P.","year":"1978","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92847-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb08940.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(59)80083-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1992.11.2.113"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91711-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970141106"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6844.28"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910220502"},{"key":"e_1_2_1_12_1","first-page":"179","article-title":"Congenital and infantile nephrotic syndromes","volume":"305","author":"Norio R.","year":"1989","journal-title":"Progr Clin Biol Res"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6653.883"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(89)90327-6"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970101107"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-45-5-1100"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90735-P"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0015-0282(16)56639-4","article-title":"Characterization of the normal progesterone and placental protein 14 responses to human chorionic gonadotropin stimulation in the luteal phase","volume":"61","author":"Batista M. C.","year":"1994","journal-title":"Fertil Steril"},{"key":"e_1_2_1_19_1","first-page":"127","article-title":"Structural studies, localization in tissue and clinical aspects of human endometrial proteins","volume":"36","author":"Sepp\u00e4l\u00e4 M.","year":"1988","journal-title":"J Reprod Fertil"},{"key":"e_1_2_1_20_1","first-page":"757","article-title":"Congenital nephrotic syndrome of the Finnish type maps to the long arm of chromosome 19","volume":"54","author":"Kestil\u00e4 M.","year":"1994","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1980.tb04620.x"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016349609054665","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016349609054665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T09:39:15Z","timestamp":1698399555000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016349609054665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,6]]}},"alternative-id":["10.3109\/00016349609054665"],"URL":"https:\/\/doi.org\/10.3109\/00016349609054665","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,6]]},"assertion":[{"value":"2011-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}