{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T06:15:56Z","timestamp":1698473756487},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T00:00:00Z","timestamp":1294358400000},"content-version":"vor","delay-in-days":5333,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic> The aim of this investigation was to study three groups of women presenting with possible HPV\u2010infection with regard to HPV\u2010types and cervical dysplasia.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> Eighty women were included. Eighteen of them were present partners to men with condylomas, 20 had clinical vulvar HPV\u2010lesions and 42 were referred due to an abnormal PAP\u2010smear. Samples for HPV\u2010analysis by PCR\u2010technique were taken from the vulva, the por\u2010tio and the cervical canal. A universal HPV\u2010primer as well as specific primers for HPV 6\/11, 16,18, 31 and 33 were utilized. PAP\u2010smears were taken as well as biopsies from cervix\/portio.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Seventy\u2010eight percent had HPV\u2010DNA identified. Sixty\u2010seven percent of those with HPV 16 and\/or 18 had dysplasia verified by histopathology and 50% of those with 31 and\/or 33. Twenty of 21 women with dysplasia had HPV 16, 18, 31 and\/or 33 identified. One woman with dysplasia was HPV\u2010negative. Histopathologically verified CIN were diagnosed in all groups investigated. Women referred for suspicion of CIN significantly more often had HPV detected at the cervix\/portio. HPV 6\/11 was mostly found in women with condylomas. Apart from this the occurrence of the different HPV types were alike in the three groups.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> Infection with HPV is a process and the usefulness of different diagnostic methods seems to depend on when during the course of the disease they are used. HPV\u2010findings in women with dysplasia were all associated with oncogenic virus\u2010types. High\u2010risk virus was often found simultaneously with low\u2010risk virus indicating a covariation in the acquisition of the different HPV\u2010types.<\/jats:p>","DOI":"10.3109\/00016349609054671","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T00:48:53Z","timestamp":1195692533000},"page":"556-562","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["HPV\u2010types, cytological and histopathological findings in three groups of women with possible HPV\u2010related disease"],"prefix":"10.1111","volume":"75","author":[{"given":"Agneta","family":"Frederiksson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbro","family":"Larson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Persson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Auer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Kalantari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geo","family":"Von Krogh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Silfversw\u00e4rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90327-H"},{"key":"e_1_2_1_3_1","first-page":"1","article-title":"Natural history of genital warts","volume":"47","author":"Oriel J. 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